Results 271 to 280 of about 72,561 (329)

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
wiley   +1 more source

The Complexity of Oxidative Stress in Human Age-Related Diseases-A Review. [PDF]

Metabolites
Płóciniczak A, Bukowska-Olech E, Wysocka E.   +2 more
europepmc   +1 more source

3P-027 Aggregation and disaggregation analysis of mutant SOD1 using fluorescence correlation spectroscopy and FLIM-FRET(The 46th Annual Meeting of the Biophysical Society of Japan)

, 2008
Akira Kitamura, Noriko Inada, Gen Matsumoto, Richard I. Morimoto, Hiroshi Kubota, Kazuhiro Nagata, Masataka Kinjo   +6 more
openalex   +2 more sources

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Multi-path direct current spinal stimulation extended survival in the SOD1-G93A model of amyotrophic lateral sclerosis. [PDF]

Front Neurol
Ahmed Z, Samaddar S, Hassieb M, Sadek R, Morozova V, Begum S.   +5 more
europepmc   +1 more source

Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures

, 2009
Lindsey R. Fischer, Jonathan D. Glass
openalex   +2 more sources

Competing chaperone pathways in α‐synuclein disaggregation and aggregation dynamics

Protein Science, Volume 34, Issue 10, October 2025.
Abstract The aggregation of the protein α‐synuclein into amyloid fibrils and their subsequent deposition into large proteinaceous inclusions is a pathological hallmark of several neurodegenerative diseases, including Parkinson's disease. Molecular chaperones, including the small heat‐shock proteins (sHsps) and the Hsp70 chaperone system, are known to ...
Nicola K. Auld, Shannon McMahon, Nicholas R. Marzano, Antoine M. van Oijen, Heath Ecroyd   +4 more
wiley   +1 more source

The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis

, 2009
Nadia D’Ambrosi, Pamela Finocchi, Savina Apolloni, Mauro Cozzolino, Alberto Ferri, Valeria Padovano, Grazia Pietrini, Maria Teresa Carrı̀, Cinzia Volonté   +8 more
openalex   +1 more source

Discovery the Mechanism of Qingdi Mixture for Radiation‐Induced Lung Injury Based on Network Pharmacology, Clinical Retrospective Analysis and Experimental Validation

Thoracic Cancer, Volume 16, Issue 19, October 2025.
Radiation‐induced lung injury (RILI) is a common complication of thoracic radiotherapy, and Qingdi mixture (QDM) has shown efficacy in its prevention. Through network pharmacology, molecular docking, and experimental validation, QDM was found to mitigate RILI primarily by inhibiting the NF‐κB signaling pathway and reducing inflammatory cytokines ...
Haoran Liu, Zhuang Yu, Qiancheng Lu, Yuke Mao, Qingzheng Liu, Shengnan Ren, Miao Zhang, Hongzong Si, Jing Wang   +8 more
wiley   +1 more source

Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms. [PDF]

PLoS Biol
Mallik B, Bhat SA, Wang X, Frank CA.
europepmc   +1 more source