Results 181 to 190 of about 5,538 (209)
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Sodium-Hydrogen Exchange and Platelet Function
Journal of Thrombosis and Thrombolysis, 1999On stimulation of platelets with agonists, for example, thrombin, a rapid rise in intracellular pH is observed. This alkalinization is mediated by an increase in transport activity of the Na(+)/H(+) exchanger isoform NHE1. In addition to this Na(+)/H(+) exchange mechanism, platelets express bicarbonate/chloride exchangers, which also contribute to pH(i)
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Sodium hydrogen exchanger inhibitory activity of benzotriazole derivatives
European Journal of Medicinal Chemistry, 2017Series of benzotriazole derivatives were synthesized and evaluated for their Sodium hydrogen exchanger-1 inhibitory potential. All compounds inhibit Sodium hydrogen exchanger-1 in the in-vitro platelet swelling assay. This is perhaps the first report of NHE-1 inhibitory activity of benzotriazole.
Dhandeep, Singh, Om, Silakari
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Microalbuminuria and Erythrocyte Sodium-Hydrogen Exchange in Essential Hypertension
Hypertension, 1995Abstract Microalbuminuria (urinary albumin excretion between 20 and 200 μg/min) and abnormalities of red blood cell sodium-hydrogen exchange coexist in essential hypertensive patients. To evaluate how the two phenomena relate, we recruited 10 untreated microalbuminuric male essential hypertensive patients without diabetes to be
GIAMPIETRO, OTTAVIO +7 more
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Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection
The Annals of Thoracic Surgery, 2003Although the mechanisms underlying ischemia/reperfusion injury remain elusive, evidence supports the etiologic role of intracellular calcium overload and oxidative stress induced by reactive oxygen species. Activation of the sodium hydrogen exchanger (NHE) is associated with intracellular calcium accumulation.
Robert M, Mentzer +3 more
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1995
The Na+/H+ exchanger (formerly antiporter) is widely distributed in nature as a component of the cell membrane. The cytosolic pH of tracheal smooth muscle, similar to many other mammalian tissues, is regulated by at least three known sarcolemmal processes.
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The Na+/H+ exchanger (formerly antiporter) is widely distributed in nature as a component of the cell membrane. The cytosolic pH of tracheal smooth muscle, similar to many other mammalian tissues, is regulated by at least three known sarcolemmal processes.
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Sodium-hydrogen exchange inhibition: pre-versus post-ischemic treatment
Basic Research in Cardiology, 2001Sodium-hydrogen exchange is involved in ischemia-reperfusion injury. Despite the strong research support for the use of sodium-hydrogen exchange blockers to protect the myocardium during ischemia-reperfusion, there is still controversy regarding the most effective time for drug delivery.
C, Hurtado, G N, Pierce
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Activity of Erythrocyte Sodium-Hydrogen Exchange in Normal Pregnancy
Clinical Science, 19971. Pregnancy is associated with a 30–50% rise in cardiac output and a 50% increase in blood volume. The contribution of changes in the activity of primary and secondary active transporters to these haemodynamic adaptations remains unknown. For the first time, we measured sodium—hydrogen exchange activity over the course of normal pregnancy.
MATTEUCCI, ELENA, GIAMPIETRO, OTTAVIO
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Sodium-hydrogen exchange system in LLC-PK1 epithelium
American Journal of Physiology-Cell Physiology, 1987Sodium influx into LLC-PK1 cells has been characterized. The main amiloride-sensitive pathway for sodium entry through the apical membrane in this cell line is sodium-hydrogen exchange with an apparent Km for sodium of 19 mM. Influx is pH dependent and is amiloride sensitive with K1/2 of 30 microM.
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Implications of sodium hydrogen exchangers in various brain diseases
Journal of Basic and Clinical Physiology and Pharmacology, 2015Abstract Na+/H+ exchangers (NHEs) are the transporter proteins that play an important role in intracellular pH (pHi) regulation, cell differentiation and cell volume and that mediate transepithelial Na+ and HCO3 − absorption on the basis of chemical gradients across the plasma membrane. Its activation causes an increase
Vivek, Verma +3 more
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Platelet sodium/hydrogen exchanger activity in normotensives and hypertensives
Clinica Chimica Acta, 1999Increased activity of sodium/hydrogen exchange provides a potentially important mechanism for the development of hypertension. The aims of this study were to compare platelet sodium/hydrogen exchanger activity and renal acid-base excretion in normotensives and hypertensives of Caucasian origin.
G A, Sagnella +3 more
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