Results 121 to 130 of about 4,957,594 (400)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Estimation of salivary sodium, potassium, and calcium levels in periodontal health and disease

Journal of Indian Society of Periodontology
Objectives: This study aimed to estimate and compare salivary sodium, potassium, and calcium levels in periodontal health and disease. Materials and Methods: A total of 150 patients were selected based on selection criteria.
Priyanka Pampani, Santhosh Shenoy, Raghavendra Vamsi Anegundi, Magesh Kumar Shekar, Kalaiselvan Dharani, Lubna Fathima   +5 more
doaj   +1 more source

Sodium rubidium hydrogen citrate, NaRbHC6H5O7, and sodium caesium hydrogen citrate, NaCsHC6H5O7: crystal structures and DFT comparisons

Acta Crystallographica Section E: Crystallographic Communications, 2019
The crystal structure of sodium rubidium hydrogen citrate, NaRbHC6H5O7 or [NaRb(C6H6O7)]n, has been solved and refined using laboratory powder X-ray diffraction data, and optimized using density functional techniques.
Andrew J. Cigler, James A. Kaduk
doaj   +1 more source

Daytime lidar measurements of tidal winds in the mesospheric sodium layer at Urbana, Illinois [PDF]

, 1986
For more than 15 years lidar systems have been used to study the chemistry and dynamics of the mesospheric sodium layer. Because the layer is an excellent tracer of atmospheric wave motions, sodium lidar has proven to be particularly useful for studying ...
Gardner, C. S., Kwon, K. H., Roesler, F. L., Sechrist, C. F., Jr., Senft, D. C., Voelz, D. G.   +5 more
core   +1 more source

Transparent dense sodium

, 2009
Under pressure, metals exhibit increasingly shorter interatomic distances. Intuitively, this response is expected to be accompanied by an increase in the widths of the valence and conduction bands and hence a more pronounced free-electron-like behaviour.
Andriy O. Lyakhov, AR Oganov, AR Oganov, Artem R. Oganov, CW Glass, E Gregoryanz, E Gregoryanz, G Kresse, G Kresse, I Tamblyn, Ivan Trojan, JB Neaton, JB Neaton, JL Dye, JM Leger, JP Perdew, JY Raty, K Shimizu, M Hanfland, M Hanfland, M Shishkin, Mario Valle, MI Eremets, MI McMahon, Mikhail Eremets, NE Christensen, PE Blöchl, S Deemyad, Sergey Medvedev, Vitali Prakapenka, VV Struzhkin, X Gonze, Y Ma, Y Ma, Yanming Ma, Yu Xie   +35 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Sex-dependent modulation of T and NK cells and gut microbiome by low sodium diet in patients with primary aldosteronism

Frontiers in Immunology
BackgroundHigh dietary sodium intake is a major cardiovascular risk factor and adversely affects blood pressure control. Patients with primary aldosteronism (PA) are at increased cardiovascular risk, even after medical treatment, and high dietary sodium ...
Hanna F. Nowotny, Tingting Zheng, Thomas Marchant Seiter, Jing Ju, Holger Schneider, Matthias Kroiss, Anna-Lina Sarkis, Lisa Sturm, Vera Britz, Andreas Lechner, Andreas Lechner, Anne L. Potzel, Anne L. Potzel, Anne L. Potzel, Sonja Kunz, Martin Bidlingmaier, Klaus Neuhaus, Adrian Gottschlich, Adrian Gottschlich, Adrian Gottschlich, Adrian Gottschlich, Sebastian Kobold, Sebastian Kobold, Sebastian Kobold, Nicole Reisch, Melanie Schirmer, Martin Reincke, Christian Adolf   +27 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Thiazide-Associated Hyponatremia and Mortality Risk: A Cohort Study

Kidney Medicine
Rationale & Objective: There are likely over 42 million patients with hypertension taking thiazides in the United States and many more worldwide. Hyponatremia is a common complication of thiazide therapy.
Steven G. Achinger, Juan Carlos Ayus, Ambuj Kumar, Athanasios Tsalatsanis   +3 more
doaj   +1 more source