Results 131 to 140 of about 5,196,702 (399)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Screening 215 Lentil Genotypes under Salinity Stress During the Seedling Stage in Greenhouse Conditions [PDF]

پژوهشنامه اصلاح گیاهان زراعی
Extended abstract Background: Salinity stress is one of the environmental stresses that significantly affects the growth of crops, especially in arid and semi-arid regions.
Ahmad Nezami, jafar Nabati, Mohammad Kafi, Elahe Boroumand Rezazadeh   +3 more
doaj  

Comparison of Urinary Sodium and Blood Pressure Relationship From the Spot Versus 24‐Hour Urine Samples

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We compared the relationship between sodium (Na) intake and blood pressure when Na intake was estimated from first‐ and second‐morning spot urine samples using the INTERSALT (International Study on Salt and Blood Pressure) formula, versus ...
Abu Mohd Naser, Mahbubur Rahman, Leanne Unicomb, Solaiman Doza, Shuchi Anand, Howard H. Chang, Stephen P. Luby, Thomas F. Clasen, K.M. Venkat Narayan   +8 more
doaj   +1 more source

Chemical Cleaning of Ultrafiltration Membrane Fouled by Humic Substances: Comparison between Hydrogen Peroxide and Sodium Hypochlorite [PDF]

, 2019
Kai Li, Shu Li, Tinglin Huang, Chongzhe Dong, Jiawei Li, Bo Zhao, Shujia Zhang   +6 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Effectiveness of a Self-monitoring Device for Urinary Sodium-to-Potassium Ratio on Dietary Improvement in Free-Living Adults: a Randomized Controlled Trial

Journal of Epidemiology, 2018
Background: Reducing the urinary sodium-to-potassium ratio is important for reducing both blood pressure and risk of cardiovascular disease. Among free-living Japanese individuals, we carried out a randomized trial to clarify the effect of lifestyle ...
Toshiyuki Iwahori, Hirotsugu Ueshima, Naoto Ohgami, Hideyuki Yamashita, Naoko Miyagawa, Keiko Kondo, Sayuki Torii, Katsushi Yoshita, Toshikazu Shiga, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura   +11 more
doaj   +1 more source

Reversible Copper Sulfide Conversion in Nonflammable Trimethyl Phosphate Electrolytes for Safe Sodium‐Ion Batteries [PDF]

, 2021
Huihua Li, Huang Zhang, Thomas Diemant, R. Jürgen Behm, Dorin Geiger, Ute Kaiser, Alberto Varzi, Stefano Passerini   +7 more
openalex   +1 more source

Optimization of cw sodium laser guide star efficiency

, 2009
Context: Sodium laser guide stars (LGS) are about to enter a new range of laser powers. Previous theoretical and numerical methods are inadequate for accurate computations of the return flux and hence for the design of the next-generation LGS systems ...
Bellanger, Bradley, Budker, d'Orgeville, D. Bonaccini Calia, D. Budker, Denman, Dmitriev, Drob, Fried, Guillet de Chatellus, Happer, Happer, Happer, Hillman, J. M. Higbie, Kartoshkin, McClelland, Milonni, Milonni, Milonni, Morris, Moussaoui, Nagengast, Pfrommer, Pique, R. Holzlöhner, Ramsey, Ressler, S. M. Rochester, Simonich, Telle, Telle, Ungar, van der Vorst, W. Hackenberg   +35 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source