Results 131 to 140 of about 167,415 (343)

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

open access: yesAdvanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song   +6 more
wiley   +1 more source

TBC1D22B Regulates ER‐to‐Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer

open access: yesAdvanced Science, EarlyView.
TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Flavia Martino   +16 more
wiley   +1 more source

Efficiency and effectiveness of physical and chemical mutagens and their combination in inducing chlorophyll mutations in M2 generation of Lablab [Lablab purpureus (l.) Sweet var. Typicus] [PDF]

open access: yesElectronic Journal of Plant Breeding, 2010
A comparative study of the frequency and spectrum of chlorophyll mutations induced by gamma rays (150, 200, 250, 300 and350 Gy), sodium azide (0.5, 1.0, 1.5 and 2.0 mM) and combination treatments of gamma rays and sodium azide (100 Gy + 1.5mM, 150 Gy + 1.
T. Raja Srinivas* and P. Veerabadhiran
doaj  

Regioselectivity in the Ring Opening of Epoxides for the Synthesis of Aminocyclitols from D-(-)-Quinic Acid

open access: yesMolecules, 2012
Efficient syntheses of four aminocyclitols are reported. Each synthesis is accomplished in eight steps starting from D-(-)-quinic acid. The key step involves a highly regioselective ring opening of epoxides by sodium azide.
Shu-Yu Yang, Tzenge-Lien Shih
doaj   +1 more source

Very high water permeability in vasopressin-induced endocytic vesicles from toad urinary bladder. [PDF]

open access: yes, 1989
The regulation of transepithelial water permeability in toad urinary bladder is believed to involve a cycling of endocytic vesicles containing water transporters between an intracellular compartment and the cell luminal membrane.
Shi, LB, Verkman, AS
core  

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

open access: yesAdvanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo   +13 more
wiley   +1 more source

Toxicological and Physiological Effects of DDT on Caenorhabditis elegans

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2016
Toxicity assays were used in this study to test how DDT affects lethality and brood size of Caenorhabditis elegans (C.elegans) by exposing them to various concentrations of this agent.
S.M. Mahmood
doaj  

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