Results 191 to 200 of about 75,606 (303)

Studies on Nucleosides and Nucleotides. IX. Nucleophilic Substitution of Secondary Sulfonyloxy Groups of Pyrimidine Nucleosides. II. Reaction of 2, 2'-Anhydro-1-(3'-O-tosyl-β-D-arabinofuranosyl) uracil with Sodium Bromide, Sodium Ethanethiol, and Sodium Azide

, 1968
Miyoshi Hirata
openalex   +2 more sources

Harnessing Aggregation‐Induced Emission‐Based Detection Toolbox for Diagnostics of Urogenital Tumors

Aggregate, Volume 6, Issue 4, April 2025.
This review provides a comprehensive overview of recent advancements in aggregation‐induced emission (AIE) biosensors for the diagnosis of urogenital system tumors, encompassing prostate, cervical, bladder, and ovarian cancers. Furthermore, it examines the various types of AIE biosensors utilized in biomarker detection, cell fluorescence imaging ...
Wenzhe Chen, Hantian Guan, Yongfeng Lu, Guohua Zeng, Di Gu, Keying Guo, Cheng Jiang, Hongxing Liu   +7 more
wiley   +1 more source

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

Angewandte Chemie, EarlyView.
A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth, Eduard Neu, Davide Provasi, Steffen Feustel, Maximilian F. Schmidt, Harald Hübner, Dorothée Weikert, Marta Filizola, Burkhard König, Peter Gmeiner   +9 more
wiley   +2 more sources

Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy

Aggregate, Volume 6, Issue 3, March 2025.
We report an innovative approach via a simple engineering strategy to construct a benzene‐fused dimer of Cy5 dye with extended π‐conjugation, resulting in an effectively narrowed energy gap, significantly enhanced photostability, redshifted absorption, and superior phototherapeutic efficacy under 808 nm near‐infrared laser excitation.
Haiqiao Huang, Qiang Liu, Jing‐Hui Zhu, Yunkang Tong, Daipeng Huang, Danhong Zhou, Saran Long, Lei Wang, Mingle Li, Xiaoqiang Chen, Xiaojun Peng   +10 more
wiley   +1 more source

A Photoactivatable Plasma Membrane Probe Based on a Self‐Triggered Photooxidation Cascade for Live Cell Super‐Resolution Microscopy

Angewandte Chemie, EarlyView.
Herein, we establish a new photoswitching concept called self‐triggered photooxidation cascade (STPC). Rhodamine dyes have mild photosensitizing properties that enable subsequent photoactivation and photobleaching of a leuco‐rhodamine plasma membrane probe.
Sonia Pfister, Valentine Le Berruyer, Kyong Fam, Mayeul Collot   +3 more
wiley   +2 more sources

CYTOLOGICAL EFFECTS OF PCMB, BAL, ISOMYTAL AND SODIUM AZIDE ON HeLa CELLS IN VITRO

, 1964
KOHTARO YAMAMOTO
openalex   +2 more sources

Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans [PDF]

, 2003
Michelle R. Massie, Elizabeth M. Lapoczka, Kristy Boggs, Karen E. Stine, Glenn E. White   +4 more
openalex   +1 more source

Fluorescent Nanoparticles Achieve Efficient Photothermal Conversion and Enhanced Antitumor Efficacy Through Intermolecular Aggregation‐Caused Quenching

Aggregate, Volume 6, Issue 3, March 2025.
A ferrocene‐based polymer nanoparticle encapsulates hydrophobic fluorescent photosensitizer, enhancing its hydrophilicity and aggregation. This aggregation induces significant aggregation‐caused quenching, which, in turn, improves photothermal conversion efficiency.
Jundong Lin, Xiaoxia Cai, Fen Zou, Wenjie Xie, Zhihao Zou, Muqi Chen, Yixun Zhang, Huichan He, Qianfeng Xu, Guowei Zhong, Shanghua Cai, Zhenjie Wu, Jianming Lu, Jianheng Ye, Yingke Liang, Yaqiang Huang, Yangjia Zhuo, Huikang Yang, Weide Zhong   +18 more
wiley   +1 more source

Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High‐Resolution Whole‐Organ 3D Mapping

Angewandte Chemie, EarlyView.
Enzymes regulate physiological functions, and their abnormal activity is associated with diseases. Here, we present a method for high‐resolution 3D mapping of enzyme activity using tissue clearing and an activity‐based covalent probe. Focusing on aminopeptidase N, we developed ANA‐o‐BODIPY, which records enzyme activity via covalent labeling.
Bo Yi, Hiroyuki Yatabe, Daichi M. Sakamoto, Iori Tamura, Yutaro Saito, Naoki Yamada, Ruki Ashikaga, Masafumi Kuroda, Shimpei I. Kubota, Kazuki Tainaka, Shinsuke Sando   +10 more
wiley   +2 more sources

Adult Neurogenesis in the Subventricular Zone of Patients with Huntington's and Parkinson's Diseases and following Long‐Term Treatment with Deep Brain Stimulation

Annals of Neurology, Volume 97, Issue 5, Page 894-906, May 2025.
Objective Parkinson's and Huntington's diseases are characterized by progressive neuronal loss. Previous studies using human postmortem tissues have shown the impact of neurodegenerative disorders on adult neurogenesis. The extent to which adult neural stem cells are activated in the subventricular zone and whether therapeutic treatments such as deep ...
Marta Snapyan, Francis Desmeules, Jonathan Munro, Morgan Bérard, Stephan Saikali, Peter V. Gould, Maxime Richer, Emmanuelle Pourcher, Mélanie Langlois, Anne‐Marie Dufresne, Michel Prud'homme, Léo Cantin, André Parent, Armen Saghatelyan, Martin Parent   +14 more
wiley   +1 more source