Results 201 to 210 of about 171,719 (347)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

open access: yesAdvanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin   +12 more
wiley   +1 more source

Reverse Mutations in Pigmentation Induced by Sodium Azide in the IR64 Rice Variety. [PDF]

open access: yesCurr Issues Mol Biol
Chen HJ   +6 more
europepmc   +1 more source

Copper Ions Reduced Toxicity of Sodium Azide and Lipopolysaccharide on Cultured Cerebellar Granule Neurons [PDF]

open access: diamond
E. V. Stelmashook   +5 more
openalex   +1 more source

Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization

open access: yesAdvanced Science, EarlyView.
In this work, we developed a post‐functionalization approach to achieve water‐soluble cyclic polyphthalaldehyde (cPPA) polymers via click chemistry. ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to
Liting He   +5 more
wiley   +1 more source

Sodium azide (NaN<sub>3</sub>) intoxication, "the man who lived": potential effective antidote and treatment strategy. [PDF]

open access: yesCrit Care
Geerdink JX   +6 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

A case report of sodium azide-induced myopericarditis. [PDF]

open access: yesEur Heart J Case Rep
Tarabanis C   +4 more
europepmc   +1 more source

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