Results 221 to 230 of about 168,123 (344)
Poly(ethylene Glycol)‐Based Peptidomimetics (Pegtides) of Antimicrobial Peptides
ChemBioChem, EarlyView.Polyethylene glycol (PEG) is commonly used to improve the pharmacokinetics and pharmacodynamics of therapeutic candidates by conjugation. Here PEG is exploited for peptidomimetic conversion of antimicrobial peptides (AMPs), as candidate antibacterial agents, by replacing their polyamide backbone. The pegtides obtained thereby can be readily synthesized
Conor Shine +13 more
wiley +1 more source
Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents
ChemBioChem, EarlyView.Photocaged methylglyoxal (PC‐MGO) derivatives enable studying protein glycation under mild conditions. The active glycating agents can be released in the protein solution by irradiating the sample with UV light. Compared to the earlier reported chemically activated MGO probes, the photocaged probes are more potent.
Saskia Sokoliova +6 more
wiley +1 more source
Cytogenetic changes induced by sodium azide (NaN3) on Trigonella foenum-graecum L. seeds
, 2007 Sazada Siddiqui +2 more
openalex +1 more source
In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins
ChemBioChem, EarlyView.This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Jan Hendrik Illies +2 more
wiley +1 more source
ChemBioChem, EarlyView.Binding studies of α‐synuclein (αS) fibril ligands using photo‐crosslinking mass spectrometry and Förster resonance energy transfer show that the multiple system atrophy (MSA)‐selective lead, HY‐215, interacts with the αS C‐terminus, unlike Parkinson's disease (PD)‐selective lead, M503. Thus, often‐ignored interactions with the disordered regions of αS
Kyle D. Shaffer +8 more
wiley +1 more source
Recent Advances in the Synthesis of 2-Substituted Oxetanes [PDF]
, 2015 Bull, JA, Davis, O
core +1 more source
C‐6‐Modified 2‐F‐Fucose Derivatives as Inhibitors of Fucosyltransferases
ChemBioChem, EarlyView.A series of C6‐modified guanosine‐diphosphate‐2‐F‐fucose analogs and corresponding prodrugs are designed, synthesized, and biologically evaluated as inhibitors of cellular fucosylation. Certain analogs potently inhibit fucosyltransferases (FUT) FUT1, 3, 6, and 9 while showing minimal activity for FUT8, highlighting the potential for selective FUT ...
Yanyan Liu, Geert‐Jan Boons
wiley +1 more source
Effect of Sodium Azide on the Growth and Variability Induction in Helianthus annuus L.
, 2010 Gehan G. Mostafa
openalex +1 more source
ChemistryEurope, EarlyView.A borrowing hydrogen strategy using an NHC‐Ir(III) catalyst enables selective N‐functionalization of unprotected amino sugars using alcohols as alkylating agents. The use of unprotected substrates avoids extra steps of protection/deprotection, minimizing waste generation.
Aitor Bermejo‐López +7 more
wiley +1 more source
Sodium azide induces mitochondria‑mediated apoptosis in PC12 cells through Pgc‑1α‑associated signaling pathway. [PDF]
Mol Med Rep, 2019 Zuo Y, Hu J, Xu X, Gao X, Wang Y, Zhu S.
europepmc +1 more source