Results 221 to 230 of about 164,723 (328)
Gamma-Ray Radiation and Sodium Azide (NaN3) Mutagenic Efficiency in Rice
Akihiko Ando, R. Montalván
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ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves+3 more
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Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma
Chromenone derivatives are synthesized and evaluated as inhibitors of chromosome region maintenance 1‐mediated nuclear export, targeting glioblastoma cells. Active compounds demonstrate structure‐ and dose‐dependent inhibition, supported by structure–activity relationships and molecular docking studies.
Salvatore Princiotto+10 more
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A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations
Site‐specifically phosphorylated isoforms of the tumor suppressor p53 – encompassing all seven known phosphorylation sites within the TAD1 domain –are created upon optimization of semisynthesis protocols. This “designer" p53 library enabled validation of phosphorylation‐specific p53 antibodies and revealed epitope masking by phosphorylation in commonly
Mateusz Hess+6 more
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Poly(ethylene glycol)‐based Peptidomimetics (Pegtides) of Antimicrobial Peptides
Cationic amphipathic poly(ethylene glycol) (PEG)‐based polymers were generated with synthetic efficiencies allowing their evaluation as Antimicrobial Peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalised with guanyl groups, but different side‐chain lengths, and hydrophobic units displaying long ...
Conor Shine+13 more
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In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska+2 more
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Cytogenetic changes induced by sodium azide (NaN3) on Trigonella foenum-graecum L. seeds
Sazada Siddiqui+2 more
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