Results 241 to 250 of about 168,123 (344)

Hybridization on DNA‐Coated Ultrasmall Gold Nanoparticles (2 nm)

open access: yesChemistry – A European Journal, EarlyView.
DNA‐conjugated ultrasmall gold nanoparticles (2 nm) hybridize with complementary DNA strands to form dimers. Covalent attachment via click chemistry preserves the DNA functionality, creating building blocks for supramolecular chemistry and controlled nanoparticle assembly.
Jonas Sager   +7 more
wiley   +1 more source

Hybrid Molecules of p53 Activators and Protoflavones to Target Multiple Myeloma

open access: yesChemMedChem, EarlyView.
Eleven hybrid compounds, designed to act by a dual mechanism of action (activation of the p53 pathway, and inhibition of ataxia telangiectasia and Rad3 related protein), were synthesized and evaluated in 5 cancer cell lines. Some hybrids exhibited nanomolar antiproliferative activity and outperformed their subunits alone and in combination ...
Francisca Lopes   +9 more
wiley   +1 more source

Opportunities and Challenges of the Application of Nuclear Magnetic Resonance‐Based Cerebrospinal Fluid Metabolomics for Clinical Research

open access: yesChemistry–Methods, EarlyView.
Cerebrospinal fluid (CSF) is an important diagnostic matrix in neurology. This review illustrates the potentials and pitfalls of current CSF analysis by nuclear magnetic resonance. Created with BioRender.com in BioRender. Berezhnoy, G. (2025) https://BioRender.com/x80l903. Web of Science is owned by Clarivate.
Georgy Berezhnoy   +4 more
wiley   +1 more source

Potential in Vitro Elicitation of Secondary Metabolite Using Sodium Azide in Tissue Culture of <em>Nigella sativa</em> and Its Eeffect on DNA Damage Inhibition

open access: green, 2020
Mohammed Shariq Iqbal   +5 more
openalex   +1 more source

Automating Synthetic Organic Electrochemistry: Concepts and Advancements

open access: yesChemistry–Methods, EarlyView.
A tutorial review on how to build an automated electrochemical flow platform, including the most relevant progresses and the future directions of the field, is studied. Automated electrochemical platforms are attracting attention for their potential in streamlining reaction preparation, electrolysis, and analysis to generate large datasets in a fast ...
Eduardo Rial‐Rodríguez   +2 more
wiley   +1 more source

Linear and Two‐Dimensional Infrared Spectroscopy of the Multifunctional Vibrational Probe, 3‐(4‐Azidophenyl) Propiolonitrile. Deperturbing a Fermi Triad by Isotopic Substitution

open access: yesChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Linear infrared spectroscopy combined with isotope labeling and density functional theory unravels the origin of a Fermi triad in a multifunctional vibrational chromophore. Ultrafast 2DIR‐spectroscopy reports directly on the dynamics and the intramolecular vibrational energy flow pathways in the isotopically deperturbed system. Abstract Infrared probes
Claudia Gräve   +4 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

open access: yesChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

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