Results 251 to 260 of about 75,606 (303)

Reviewing Glycosyl‐Inositols: Natural Occurrence, Biological Roles, and Synthetic Techniques

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
Overall, this comprehensive review underscores the significance of glycosyl inositols as versatile molecules with diverse biological functions and promising applications in scientific research and industry. Methods for their chemical and enzymatic synthesis are also reviewed, highlighting recent advances and challenges in the field.
Alfonso Miranda‐Molina, Laura Alvarez, Mayra Antunez‐Mojica, Benjamín Velasco‐Bejarano   +3 more
wiley   +1 more source

Proteome‐Wide Profiling of Olaparib Interactors Using a Biotinylated Photoaffinity Probe

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
Novel interactors found for olaparib: Olaparib is an important anti‐cancer drug in BRCA‐mutated cancers. In this study, we identified novel interactors for olaparib using photoaffinity labeling. We designed a biotinylated photoaffinity probe and used it in a proteomic screening to discover a broad range of olaparib interactors, including previously ...
Femke L. A. M. van der Heijden, Suzanne A. Weijers, Onno Bleijerveld, Katarzyna W. Kliza, Michiel Vermeulen, Dmitri V. Filippov   +5 more
wiley   +1 more source

Chondroitin Sulfate‐Coated Heteroduplex‐Molecular Spherical Nucleic Acids

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
[60]fullerene‐based molecular spherical nucleic acids (MSNAs) were used as hybridization‐mediated carriers for an antisense oligonucleotide, suppressing Tau protein, and its conjugates with chondroitin sulfate (CS) tetrasaccharides. The impact of the MSNA‐carriers and the CS‐halo on the cellular uptake and suppression of Tau‐protein was studied with ...
Toni Laine, Prasannakumar Deshpande, Ville Tähtinen, Eleanor T. Coffey, Pasi Virta   +4 more
wiley   +1 more source

Synthesis and Preliminary Evaluation of Tanshinone Mimic Conjugates for Mechanism of Action Studies

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
A small array of Tanshinone Mimics (TM) probes with a detection‐promoting moiety (either a photoaffinity probe ‐ PAP or biotin) has been synthesized for mechanism of action (MoA) studies on Human antigen R (HuR). Biological and biochemical assays were used to characterize the novel TM conjugates.
Giulia Assoni, Ágata Sofia Assunção Carreira, Matteo Tomiello, Pierfausto Seneci, Alessandro Provenzani, Daniela Arosio   +5 more
wiley   +1 more source

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

ChemBioChem, EarlyView.
This study reports the synthesis of five tetrazine‐coordinated, half‐sandwich iridium complexes and extensively describe their reactivity. Live cell fluorescent bioorthogonal labeling reveals the nuclear tropism of the most cytotoxic complex. Intracellular imaging of anticancer metallodrugs often relies on prelabeling with organic fluorophores, which ...
Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot, Michèle Salmain   +6 more
wiley   +1 more source

Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide‐Activated ClpP in Bacillus Subtilis

ChemBioChem, EarlyView.
FtsZ is the only target protein that has been biochemically confirmed to be hydrolyzed both in vitro and in bacterial cells. Coupled with activity‐based protein profiling of nonribosomal peptide synthetases, the ClpP‐ADEP1 proteolytic complex that degrades the surfactin synthetases SrfAA and SrfAB in cell lysates and bacterial cells is demonstrated ...
Fumihiro Ishikawa, Chiharu Uchida, Rina Ohnishi, Taketo Imai, Genzoh Tanabe   +4 more
wiley   +1 more source

Inhibition of Surfactin Biosynthesis in Bacillus Subtilis Using Cell‐Permeable Adenylation Domain Inhibitors

ChemBioChem, EarlyView.
L‐Leu‐AMS‐based adenylation domain inhibitors with the modification of 2′‐OH in the adenosine skeleton are synthesized. Coupled with affinity‐based protein profiling of nonribosomal peptide synthetases (NRPSs), their activities toward surfactin‐NRPSs in Bacillus subtilis are evaluated.
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe   +3 more
wiley   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, EarlyView.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern, Exequiel O. J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul W. Denny, Patrick G. Steel   +7 more
wiley   +1 more source

Chromenone derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, Accepted Article.
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Wolfgang Link, Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea-Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira   +10 more
wiley   +1 more source

Synthesis of 2‐substituted ATP derivatives and their use in enzymatic synthesis and postsynthetic labelling of RNA

ChemBioChem, Accepted Article.
A series of adenosine triphosphate derivatives bearing chloro, fluoro, amino, methyl, vinyl and ethynyl groups at position 2 were synthesized and tested as substrates for RNA and DNA polymerases. The modified nucleotides worked well in in vitro transcription with T7 polymerase and primer extension (PEX) using engineered DNA polymerases (TGK, 2M) except
Ugnė Šinkevičiūtė, Tania Sanchez-Quirante, Samanta Rožánková, Lenka Poštová Slavětínská, Veronika Raindlová, Michal Hocek   +5 more
wiley   +1 more source