Results 251 to 260 of about 164,723 (328)

Potential in Vitro Elicitation of Secondary Metabolite Using Sodium Azide in Tissue Culture of <em>Nigella sativa</em> and Its Eeffect on DNA Damage Inhibition

open access: green, 2020
Mohammed Shariq Iqbal   +5 more
openalex   +1 more source

Development of CPA‐Catalyzed β‐Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs

open access: yesChemistry – A European Journal, EarlyView.
We describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Natasha Perry   +3 more
wiley   +1 more source

New Click on the Block: Photocaged Hydroxylamine, an Addition to the Light‐Activatable Bioorthogonal Toolbox

open access: yesChemistry – A European Journal, Accepted Article.
Krisztina Németh,†,[a] Flóra Horváth,†,[a] Ágnes Szatmári,[a] Evelin Albitz,[a] Péter Kele*[a] and Gergely B. Cserép*[a] A new photoactivatable bioorthogonal function was added to the photoactivatable bioorthogonal toolbox by transiently disabling the bioorthogonal reactivity of the hydroxylamine moiety with a photolabile protecting group.
Krisztina Németh   +5 more
wiley   +1 more source

Double‐Click Strategy Combining CuAAC and (Thia‐) Diels‐Alder Reactions; Application towards Peptide Labeling

open access: yesChemistry – A European Journal, Accepted Article.
We report an efficient double‐click strategy combining copper‐catalyzed azide–alkyne cycloaddition (CuAAC) with (thia‐)Diels–Alder (DA) reactions, enabled by newly designed heterobifunctional platforms bearing orthogonal clickable groups: alkyne–dithioester, alkyne–maleimide, or azide–diene.
Timothé Maujean   +7 more
wiley   +1 more source

Sequential Polymerization of Nitrogen at High Pressures

open access: yesChemistry–Methods, EarlyView.
Polynitrogen anions, including N2, N4, N6 rings, N18 rings, and N chains, form under high pressure. These anions exhibit unique bonding structures that are stabilized in such conditions. Detailed information regarding their formation and properties is available in the article.
Huawei Chen   +2 more
wiley   +1 more source

A Scalable L‐α‐Glycerophosphorylcholine Synthesis through the Automatic pH‐Controlled (R)‐Glycidol Ring Opening with Phosphorylcholine

open access: yesChemistry–Methods, EarlyView.
Automatic titrator enables the regioselective ring opening of (R)‐glycidol in water in the presence of phosphorylcholine, leading to the synthesis of L‐α‐glycerophosphorylcholine, a commercially available drug, in very high yield. The reaction is triggered by a minimum amount of NaOH and reactants, while the optimal pH is precisely regulated through ...
Antonio Massa   +2 more
wiley   +1 more source

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