The Reaction Mechanism of the Azide-Alkyne Huisgen Cycloaddition [PDF]
Phys. Chem. Chem. Phys., 2019, 21, 19281-19287, 2020 The azide-alkyne Huisgen cycloaddition has a key role in click chemistry and configures as powerful tool in pharmaceutical and medicinal chemistry. Although this reaction has already been largely studied, there is an ongoing debate about its mechanism. In this work we study the dynamical aspects of the process using metadynamics computer simulation. We
arxiv +1 more source
Alkylating efficiency of sodium azide on pod yield, nut size and nutrition composition of Samnut 10 and Samnut 20 varieties of groundnut (Arachis hypogea L.) [PDF]
, 2015 Mutation has been utilised to improve growth and yield of many food crops, but only little effort has been made to ascertain the nutritional advantages in such improved crops.
Animasaun, D A +3 more
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CHIMIA, 2003 Azides are very versatile precursors of organic synthesis functionalities such as amines, isocyanates, sulfonamides, triazoles, tetrazoles, triazolines, aziridines, amino acids and diazo compounds.
Jean-Pierre Hagenbuch
doaj +1 more source
Site-Selective Dynamics of Ligand-Free and Ligand-Bound Azidolysozyme [PDF]
, 2021 Azido-modified alanine residues (AlaN$_3$) are environment-sensitive, minimally invasive infrared probes for the site-specific investigation of protein structure and dynamics. Here, the capability of the label is investigated to query whether or not a ligand is bound to the active site of Lysozyme and how the spectroscopy and dynamics change upon ...
arxiv +1 more source
Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells [PDF]
, 2013 Heat Shock Proteins 60 & 70 (HSP60 & HSP70) are intracellular protein that has been shown to be present at elevated levels in systemic circulation in Type 2 Diabetes mellitus (T2DM) patients.
Hall, Luke, Martinus, Ryan Dennis
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Lattice dynamics and electronic structure of energetic solids LiN3 and NaN3: A first principles study [PDF]
Chemical Physics Letters, Volume 586, Page no 44 (2013), 2013 We report density functional theory calculations on the crystal structure, elastic, lattice dynamics and electronic properties of iso-structural layered monoclinic alkali azides, LiN3 and NaN3. The effect of van der Waals interactions on the ground- state structural properties is studied by using various dispersion corrected density functionals.
arxiv +1 more source
Short term minutes-time scale temporal variation statistics of sodium layer dynamics [PDF]
, 2021 The brightness and height of the sodium laser guide star of adaptive optics could vary significantly due to the temporal dynamics of sodium column density and the mean height of sodium layer. To measure these dynamics, an independent sodium Lidar is a necessity.
arxiv +1 more source
Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid [PDF]
, 2012 A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and ...
Amantini +33 more
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Temperature increase exacerbates apoptotic neuronal death in chemically-induced ischemia. [PDF]
PLoS ONE, 2013 It is well-established that hyperthermia increases neuronal death and worsens stroke outcome. However, little is known about the mechanisms of how hyperthermia is involved in this neuronal death process.
Chunyan He +3 more
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Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]
, 2014 The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W. +6 more
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