Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles
Beilstein Journal of Organic Chemistry, 2013 A microwave-assisted three-component protocol involving N-1 alkylation of 2-alkynylindoles with epichlorohydrin, ring opening of the epoxide with sodium azide, and an intramolecular Huisgen azide–internal alkyne 1,3-dipolar cycloaddition domino sequence ...
Rajesh K. Arigela +3 more
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Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors [PDF]
, 2019 Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that a non-heme iron enzyme can catalyze olefin aziridination and nitrene C–H insertion, and that these activities can be improved by directed evolution ...
Arnold, Frances H. +3 more
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Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells [PDF]
, 2013 Heat Shock Proteins 60 & 70 (HSP60 & HSP70) are intracellular protein that has been shown to be present at elevated levels in systemic circulation in Type 2 Diabetes mellitus (T2DM) patients.
Hall, Luke, Martinus, Ryan Dennis
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CHIMIA, 2003 Azides are very versatile precursors of organic synthesis functionalities such as amines, isocyanates, sulfonamides, triazoles, tetrazoles, triazolines, aziridines, amino acids and diazo compounds.
Jean-Pierre Hagenbuch
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Ceruloplasmin Interferes with the Assessment of Blood Lipid Hydroperoxide Content in Small Ruminants
Antioxidants, 2023 Simple and inexpensive analytical methods for assessing redox balance in biological matrixes are widely used in animal and human diagnostics. Two of them, reactive oxygen metabolites (ROMs) and total oxidant status (TOS), evaluate the lipid hydroperoxide
Stefano Cecchini Gualandi, Raffaele Boni
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End-group functionalization of poly(2-oxazoline)s using methyl bromoacetate as initiator followed by direct amidation [PDF]
, 2019 Poly(2-alkyl/aryl-2-oxazoline)s (PAOx) are an alluring class of polymers for many applications due to the broad chemical diversity that is accessible for these polymers by simply changing the initiator, terminating agent and the monomer(s) used in their ...
Arys, Koen +4 more
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6-Deoxyhexoses froml-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology [PDF]
, 2016 In the search for alternative non‐metabolizable inducers in the l ‐rhamnose promoter system, the synthesis of fifteen 6‐deoxyhexoses from l ‐rhamnose demonstrates the value of synergy between biotechnology and chemistry.
Estévez, Amalia +12 more
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Temperature increase exacerbates apoptotic neuronal death in chemically-induced ischemia. [PDF]
PLoS ONE, 2013 It is well-established that hyperthermia increases neuronal death and worsens stroke outcome. However, little is known about the mechanisms of how hyperthermia is involved in this neuronal death process.
Chunyan He +3 more
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The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae. [PDF]
, 2008 BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis.
Fisher, LM +5 more
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HoehneaChemical mutagens (e.g. sodium azide and nitrous acid) are important tools in crop improvements because they produce resistance against pathogens in crops to improve their yield and quality traits. This study investigates the morphological and anatomical
A.A. AbdulRahaman +4 more
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