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Neurology, 2007
Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
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Voltage-gated sodium (Na+) channels play a key role in membrane excitation in neurons. These channels have a critical role in the development and maintenance of several pain syndromes, including inflammatory pain, neuropathic pain, and central pain associated with spinal cord injury.1–4 The increasing understanding of the molecular organization ...
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Science, 2019
Ion Channels Voltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these channels, making it challenging to develop specific therapeutics. A core α subunit is sufficient for voltage sensing and ion conductance, but function is modulated by β subunits and by natural toxins that can ...
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Ion Channels Voltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these channels, making it challenging to develop specific therapeutics. A core α subunit is sufficient for voltage sensing and ion conductance, but function is modulated by β subunits and by natural toxins that can ...
openaire +1 more source
Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels
2014Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts.
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Open-state structure and pore gating mechanism of the cardiac sodium channel
Cell, 2021Daohua Jiang +2 more
exaly
Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
Lancet, The, 2005Martin Dichgans +2 more
exaly
Sodium-channel defects in benign familial neonatal-infantile seizures
Lancet, The, 2002Sarah E Heron +2 more
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