Results 51 to 60 of about 1,776,084 (300)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation [PDF]

, 2023
Dietary potassium (K+) supplementation is associated with a blood pressure (BP) lowering effect, but not all studies agree. Here we examined the effects of short and long-term K+ supplementation on BP in mice, whether differences depend on the ...
Hoorn, Ewout J.; id_orcid, Assmus, Adrienne, Grimm, Paul R., Ivy, Jessica R., Hoorn, Ewout J., Murali, Sathish K., Cheng, Lei, Matchkov, Vladimir, Little, Robert, Welling, Paul A., Matchkov, Vladimir V., Poulsen, Søren B., Fenton, Robert A., Ewout J. Hoorn, Paul A. Welling, Adrienne Assmus, Søren B. Poulsen, Robert Little, Robert A. Fenton, Jessica R. Ivy, Sathish K. Murali, Vladimir Matchkov, Paul R. Grimm, Lei Cheng   +23 more
core   +1 more source

An Engineered Thio‐Amino Polymer Achieves Potent, Safe, and Broad Cell Type Delivery in the Lung Mapped by Spatial Transcriptomics

Advanced Materials, EarlyView.
Synthesis and screening of a polymer library produced a versatile and inhalable mRNA vehicle for the lungs (P81). Compared to a published LNP, P81 provides increased delivery efficacy, achieving widespread expression in broad cell types, with no toxicity.
Pramodkumar EK, Younghun Jung, Elex S. Rose, Jae Yeon Joo, James R. Rose, José A. F. Assumpção, Hyeyoon Jeong, Lorena C. S. Chaves, Blake Andrew Miller, João Paulo Pera Mendes, Hannah E. Peck, Charmy J. Patel, Loren E. Sasser, Heather Pathak, Varun V. Mosur, Jaehyeon Hwang, Guilherme de Oliveira Lopes, Merrilee Thoresen, Santiago Cornejo, Peres Badial, Alicia Olivier, Amelia R. Woolums, Samuele Stazzoni, Noemi Manganaro, Eleonora Nencini, Giulio Pierleoni, Emanuele Andreano, Rino Rappuoli, Nichole Orr‐Burks, Sarah R. Hosking, Nicholas S. Heaton, Eric R. Lafontaine, Robert J. Hogan, Francois Villinger, Daryll Vanover, Chiara Zurla, Philip J. Santangelo   +36 more
wiley   +1 more source

Association of Parenting Style and Mindful Eating with Sodium Intake among Adolescents in Indonesia

Makara Journal of Health Research, 2023
Background: Most adolescents have an excessive sodium intake associated with hypertension and cardiovascular disease (CVD). Parents have an important role in controlling adolescents’ nutritional intake, including sodium, through healthy eating.
Rizqy Amanatul Husna Pamungkas, Erfi Prafiantini, Dian Novita Chandra   +2 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Effects of dietary sodium chloride on chloride cell development and growth of rainbow trout [PDF]

, 1999
The effects of increased dietary salt on growth and morphology and numbers of chloride cells of rainbow trout (Oncorhynchus mykiss) were investigated using three isonitrogenous and isocaloric diets containing 1.5, 4.5 and 10.5% sodium chloride ...
Gong, Jingjuan
core  

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

THE INVESTIGATION OF THE PENETRATION OF MICROELEMENTS OF A DIETARY SUPPLEMENT IN CRUCIAN MEAT BY VARIOUS METHODS OF SALTING

Harčova Nauka ì Tehnologìâ, 2021
The expediency of improving the technological methods of processing unprofitable small fish and expanding the range of food products from them is substantiated. It is proposed to enrich the meat of freshwater fish with trace elements by adding to salt or
M. Golovko, T. Golovko, A. Pak, L. Krykunenko   +3 more
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Alginates as food ingredients absorb extra salt in sodium chloride-treated mice

Heliyon, 2021
Many patients with impaired renal function undergoing dialysis are subject to severe dietary restrictions. Especially overdose of salt is related to crisis of their life, so their meals are basically salt-free or low salt.
Yukio Fujiwara, Ryoko Maeda, Hidenori Takeshita, Yoshihiro Komohara   +3 more
doaj   +1 more source