Results 31 to 40 of about 4,509 (135)

Aquaporins: important but elusive drug targets. [PDF]

, 2014
The aquaporins (AQPs) are a family of small, integral membrane proteins that facilitate water transport across the plasma membranes of cells in response to osmotic gradients.
A Bergamo, A Burykin, A Kimura, A Rossi, A Warth, A Warth, AB Chepelinsky, AJ Smith, AJ Yool, AJ Yool, Alan S. Verkman, AP Martins, AP Martins, AS Verkman, AS Verkman, B Bassarak, B Bertrand, B Ma, B Yang, B Yang, B Yang, B Yang, B Zhang, BC Kieseier, BJ Baum, BJ Baum, BJ Jin, BK Tamarappoo, BL de Groot, C Esteva-Font, C Goubau, C Maurel, CL Chou, CM Niemietz, D Fu, D Fu, D Seeliger, D Wesche, D Zhang, DC Blaydon, DG Bichet, DK Binder, DM Wingerchuk, E Beitz, E Lindahl, E Migliati, E Solenov, E Soupene, EM Muller, EM Nagy, ET Olesen, EW Miller, F Baumgart, FJ Detmers, G Di Giusto, G Fischer, G Soveral, G Soveral, GM Preston, GM Preston, GP Bienert, GP Nicchia, GT Manley, H Chen, H Hasegawa, H Sui, H Tsukaguchi, H Zhang, HJ Jung, HL Brooks, J Badaut, J Farinas, J Farinas, J Farinas, J Gao, J Hu, J Li, J Li, J Liu, J Palace, J Schnermann, JD Ho, JE Rash, JF Kun, JJ Iliff, JJ Irwin, JL Edelman, JM Crane, JP Morello, JR Thiagarajah, JS Hub, K Ishibashi, K Miranda, K Murata, K Oshio, K Oshio, K Oshio, KI Auguste, L Janosi, L Tradtrantip, L Tradtrantip, L Tradtrantip, L Tradtrantip, LJ Galietta, LM Holm, LS King, M Amiry-Moghaddam, M Araki, M Boone, M Dumas, M Endo, M Hara, M Hara-Chikuma, M Hara-Chikuma, M Hara-Chikuma, M Hara-Chikuma, M Herrera, M Kato, M Moore, M Ozu, M Ozu, Marc O. Anderson, Marios C. Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MC Papadopoulos, MG Mola, MH Levin, MH Levin, MJ Tait, MP Marrades, N Chihara, N Maeda, N Roudier, N Roudier, N Zhu, NN Haj-Yasein, O Bloch, O Bloch, P Padmawar, PM Deen, PW Phuan, R Gao, R Katada, R Musa-Aziz, R Zhang, RB Zhang, RI Macey, S Jelen, S Jelen, S Nielsen, S Nielsen, S Pavlovic-Djuranovic, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Saadoun, S Sasaki, S Tornroth-Horsefield, SD Shields, SJ Wacker, SR Hinson, SR Hinson, T Gonen, T Hibuse, T Ma, T Ma, T Ma, T Ma, T Ma, T Yamamoto, T Zeuthen, TH Kwon, TL Pallone, V Berry, VA Lennon, VA Lennon, VJ Huber, VJ Huber, W Castro-Borges, X Cao, Y Liu, Y Morishita, Y Song, Y Song, Y Wang, YB Zhang, YH Huang, Z Zhang, ZH Li   +194 more
core   +1 more source

Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter [PDF]

, 2012
Background: The purine-cytosine FcyB transporter is a prototype member of the NCS1 family. Results: Using homology modeling, substrate docking, and rational mutational analysis, we identify residues critical for function and specificity.
Amillis, Sotiris, Diallinas, George, Kosti, Vasiliki, Krypotou, Emilia, Mikros, Emmanuel, Myrianthopoulos, Vassilios   +5 more
core   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19. [PDF]

, 2016
Acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC) are both members of the ENaC/degenerin family of amiloride-sensitive Na(+) channels.
Alijevic, O., Boscardin, E., Frateschi, S., Hummler, E., Kellenberger, S.   +4 more
core   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

The elements of life and medicines [PDF]

, 2015
Which elements are essential for human life? Here we make an element-by-element journey through the periodic table and attempt to assess whether elements are essential or not, and if they are, whether there is a relevant code for them in the human genome.
Chellan , Prinessa, Sadler, P. J.
core   +1 more source

Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)

American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.
ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone, Alessia Nisco, Luciana de Gennaro, Maria Tolomeo, Elisa Lorefice, Giuseppe Petrosillo, Silvia Russo, Donatella De Giovanni, Claudia Rita Catacchio, Francesca Romana Lepri, Mario Ventura, Simonetta Simonetti, Albina Tummolo, Maria Barile   +13 more
wiley   +1 more source

Diseases associated with general amino acid transporters of the solute carrier 6 family (SLC6)

, 2015
Amino acid transporters of the SLC6 family mediate the Na⁺-dependent uptake of neutral amino acids into neurons and epithelial cells of the intestine, kidney and other organs.
Bröer, Stefan
core   +1 more source

The Rotavirus Enterotoxin NSP4 Directly Interacts with the Caveolar Structural Protein Caveolin-1 [PDF]

, 2006
Rotavirus nonstructural protein 4 (NSP4) is known to function as an intracellular receptor at the endoplasmic reticulum (ER) critical to viral morphogenesis and is the first characterized viral enterotoxin.
Ball, Judith M., McIntosh, Avery, Mir, Kiran D., Mitchell, DeAnne M., Parr, Rebecca D., Storey, Stephen M., Zhou, Minglong   +6 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source