Results 31 to 40 of about 144,588 (306)
Проблеми екології та медицини, 2023 Over the past century, since the rapid development of mankind as a civilization, the state of the environment and the conditions of everyday human existence have undergone significant changes.
O.V. Mamai, S.M. Bilash, R.M. Grinko
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EFSA Journal, 2017 The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of glutamic acid–glutamates (E 620–625) when used as food additives.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) +27 more
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Regenerative glutamate release in the hippocampus of Rett syndrome model mice. [PDF]
PLoS ONE, 2018 Excess glutamate during intense neuronal activity is not instantly cleared and may accumulate in the extracellular space. This has various long-term consequences such as ectopic signaling, modulation of synaptic efficacy and excitotoxicity; the latter ...
Saju Balakrishnan, Sergej L Mironov
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Methodology for measuring the mass fraction of monosodium glutamate in meat matrices [PDF]
BIO Web of ConferencesOver the past century, human lifestyles and eating habits have changed dramatically as people in developed countries resort to fast food, they are indiscriminate and get used to frequent snacking. Production of dietary dishes and increase in the range of
Knyazeva A.C. +4 more
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Biology and Life Sciences Forum, 2022 Monascus purpureus is produced in Asia and used as a food dye and for medicinal purposes. In the present study, the radial growth of quinoa flour-based culture media was evaluated on the tenth day after cultivation with different sources of carbon ...
Evelyn Quispe-Rivera +5 more
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
Frontiers in Cellular Neuroscience, 2019 Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate ...
Joana Gonçalves-Ribeiro +7 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source