Results 31 to 40 of about 130,089 (333)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels
Cell Reports, 2021 Summary: Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear ...
Cyril Cheret +4 more
doaj
Проблеми екології та медицини, 2023 Over the past century, since the rapid development of mankind as a civilization, the state of the environment and the conditions of everyday human existence have undergone significant changes.
O.V. Mamai, S.M. Bilash, R.M. Grinko
doaj +1 more source
Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective [PDF]
BMC Systems Biology 7:103 (2013), 2013 The energetics of cerebral activity critically relies on the functional and metabolic interactions between neurons and astrocytes. Important open questions include the relation between neuronal versus astrocytic energy demand, glucose uptake and intercellular lactate transfer, as well as their dependence on the level of activity.
arxiv +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
MicroorganismsNatural astaxanthin is in high demand due to its multiple health benefits. The microalga Haematococcus lacustris has been used for the commercial production of astaxanthin.
Vijay Rayamajhi +10 more
doaj +1 more source
EFSA Journal, 2017 The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of glutamic acid–glutamates (E 620–625) when used as food additives.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) +27 more
doaj +1 more source
Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells
Biomolecules, 2020 Sulfation is a common modification of extracellular glycans, tyrosine residues on proteins, and steroid hormones, and is important in a wide variety of signaling pathways.
Haruna Nagase +4 more
doaj +1 more source
Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling +6 more
wiley +1 more source
Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
Frontiers in Cellular Neuroscience, 2019 Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate ...
Joana Gonçalves-Ribeiro +7 more
doaj +1 more source