Results 41 to 50 of about 140,750 (306)
Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors
Neurobiology of Disease, 2007 Axonal injury in white matter is an important consequence of many acute neurological diseases including ischemia. A role for glutamate-mediated excitotoxicity is suggested by observations from in vitro and in situ models that AMPA/kainate blockers can ...
Suzanne M. Underhill, Mark P. Goldberg
doaj +1 more source
FEBS Letters, EarlyView.We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio +9 more
wiley +1 more source
Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells
Biomolecules, 2020 Sulfation is a common modification of extracellular glycans, tyrosine residues on proteins, and steroid hormones, and is important in a wide variety of signaling pathways.
Haruna Nagase +4 more
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Regenerative glutamate release in the hippocampus of Rett syndrome model mice. [PDF]
PLoS ONE, 2018 Excess glutamate during intense neuronal activity is not instantly cleared and may accumulate in the extracellular space. This has various long-term consequences such as ectopic signaling, modulation of synaptic efficacy and excitotoxicity; the latter ...
Saju Balakrishnan, Sergej L Mironov
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Biology and Life Sciences Forum, 2022 Monascus purpureus is produced in Asia and used as a food dye and for medicinal purposes. In the present study, the radial growth of quinoa flour-based culture media was evaluated on the tenth day after cultivation with different sources of carbon ...
Evelyn Quispe-Rivera +5 more
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Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Methodology for measuring the mass fraction of monosodium glutamate in meat matrices [PDF]
BIO Web of ConferencesOver the past century, human lifestyles and eating habits have changed dramatically as people in developed countries resort to fast food, they are indiscriminate and get used to frequent snacking. Production of dietary dishes and increase in the range of
Knyazeva A.C. +4 more
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
EFSA Journal, 2017 The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re‐evaluating the safety of glutamic acid–glutamates (E 620–625) when used as food additives.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) +27 more
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Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity
Frontiers in Cellular Neuroscience, 2019 Glutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate ...
Joana Gonçalves-Ribeiro +7 more
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