Results 41 to 50 of about 5,265 (145)

Rapid reductions in prices for generic sofosbuvir and daclatasvir to treat hepatitis C

Journal of Virus Eradication, 2016
Objectives: Novel treatments for hepatitis C demonstrate high cure rates, but current high prices can be a barrier to rapid global treatment scale-up. Generic competition can rapidly lower drug prices.
Andrew Hill, Bryony Simmons, Dzintars Gotham, Joseph Fortunak   +3 more
doaj   +1 more source

Absence of progressive liver disease after treatment in children with chronic hepatitis C: A nationwide registry study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives In adults with chronic hepatitis C (CHC) and advanced fibrosis, hepatocellular carcinoma (HCC) surveillance is recommended after achieving a sustained virologic response (SVR). However, post‐SVR surveillance strategies for children remain unclear. The aim of this study was to assess the durability of SVR and determine an appropriate
Hitoshi Tajiri, Mitsuyoshi Suzuki, Yuri Etani, Yoshinori Ito, Koichi Ito, Tomoya Fukuoka, Tatsuki Mizuochi   +6 more
wiley   +1 more source

Cost-utility analysis of four WHO-recommended sofosbuvir-based regimens for the treatment of chronic hepatitis C in sub-Saharan Africa

BMC Health Services Research, 2022
Background Although direct-acting antivirals (DAA) have become standard care for patients with chronic hepatitis C worldwide, there is no evidence for their value for money in sub-Saharan Africa.
Sylvie Boyer, Maël Baudoin, Marie Libérée Nishimwe, Melina Santos, Maud Lemoine, Gwenaëlle Maradan, Babacar Sylla, Charles Kouanfack, Patrizia Carrieri, Abbas Mourad, Nicolas Rouveau, Raoul Moh, Moussa Seydi, Alain Attia, Maame Esi Woode, Karine Lacombe   +15 more
doaj   +1 more source

Suspected fibrosing cholestatic hepatitis in an immunocompetent child with hepatitis C: Case report

JPGN Reports, EarlyView.
Abstract A 12‐year‐old boy presented to our center with elevated aminotransferases, jaundice, right upper quadrant tenderness, and hepatomegaly. Evaluation revealed a highly elevated blood hepatitis C virus (HCV) ribonucleic acid (RNA) level, and liver biopsy showed canalicular and intrahepatic cholestasis, feathery degeneration of hepatocytes, and ...
Sara Bohon, Regino Gonzalez‐Peralta, Robert J. Fontana, Richard Cordle, Robin LeGallo, Frank DiPaola   +5 more
wiley   +1 more source

Serum Agalactosyl IgG Predicts Hepatocellular Carcinoma and All‐Cause Mortality After SVR in Advanced Chronic Hepatitis C

Hepatology Research, EarlyView.
ABSTRACT Background and Aims Patients with chronic hepatitis C and advanced fibrosis remain at substantial risk of hepatocellular carcinoma (HCC) and non‐liver–related death even after sustained virological response (SVR) to direct‐acting antivirals (DAA).
Daisuke Sakon, Jumpei Kondo, Yuki Tahata, Hayato Hikita, Maki Iwaisako, Muya Matsumoto, Asuka Ogata, Shinji Takamatsu, Yasutoshi Nozaki, Naruyasu Kakita, Hisashi Ishida, Fumihiko Nakanishi, Yuichi Yoshida, Masanori Nakahara, Kazuho Imanaka, Mitsuru Sakakibara, Takayuki Yakushijin, Tetsuo Takehara, Takahiro Kodama, Eiji Miyoshi   +19 more
wiley   +1 more source

Development and validation of RP HPLC method for the estimation of Sofosbuvir and related impurity in bulk and pharmaceutical dosage form

Future Journal of Pharmaceutical Sciences, 2021
Background The present work is aimed at development and validation of RP HPLC method which is simple, specific, precise, and accurate for estimation of Sofosbuvir and its process-related impurity in bulk and pharmaceutical dosage forms.
Shiny Ganji, Satyavati Dhulipala, Appala Raju Nemala   +2 more
doaj   +1 more source

Changes in cardiometabolic biomarkers 1 year after direct acting antiviral therapy for hepatitis C virus co‐infection among people with HIV

HIV Medicine, EarlyView.
Abstract Objectives Among people with HIV with hepatitis C virus (HCV) co‐infection, we examined differences in haemoglobin A1c (HbA1c), total cholesterol (TC), low‐density lipoprotein (LDL), high‐density lipoprotein (HDL) and atherosclerotic cardiovascular disease (ASCVD) risk score at 12‐months following direct acting antiviral (DAA) initiation ...
Raynell Lang, Elizabeth Humes, Asya Lyass, Leila H. Borowsky, Brenna Hogan, Arthur Y. Kim, Michael LaValley, Jennifer O. Lam, Ditipriya Bhar, Richard D. Moore, Frank Palella, Heidi Crane, Michael Horberg, Sonia Napravnik, Virginia A. Triant, Keri N. Althoff, on behalf of the North American AIDS Cohort Collaboration on Research and Design (NA‐ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (IeDEA)   +16 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Sofosbuvir‐Based Therapy in Chinese Children and Adolescents With Chronic HCV Infection: A Retrospective Multicentre Study

Journal of Viral Hepatitis, Volume 33, Issue 12, December 2026.
ABSTRACT Few direct‐acting antiviral regimens are approved in China for children and adolescents with chronic hepatitis C virus (HCV) infection and data are limited on their efficacy and safety in this population. This retrospective, multi‐centre study aimed to assess the real‐world effectiveness and safety of ledipasvir/sofosbuvir (LDV/SOF) and ...
Li Liu, Mei Li, Shishu Zhu, Yi Dong, Hongmei Zu, Ping Yu, Ruiling Liu, Yan Chen, Joshua Lin, Carl Gustafson, Heribert Ramroth, Lin Liu, Yanwen Luo   +12 more
wiley   +1 more source

Evolution of Hepatitis C Virus Treatment During the Era of Sofosbuvir-Based Therapies: A Real-World Experience in France

, 2021
International audienceBackground Treatment of hepatitis C virus (HCV) has been dramatically improved with the introduction of direct-acting antiviral agents (DAAs).
Ouzan, Denis, Glorian-Petraud, Denise, Roulot, Dominique, Leroy, Vincent, Heluwaert, Frederic, Dumortier, Jérôme, Guyader, Dominique, Libert, Olivier, Roche, Bruno, Pol, Stanislas, Rosa, Isabelle, Thiefin, Gerard, Combis, Jean-Marc, Hezode, Christophe, Asselah, Tarik, Larrey, Dominique, Riachi, Ghassan, Ramroth, Heribert, Remy, Andre-Jean, Truchi, Regine, Bailly, Francois, Thabut, Dominique   +21 more
core   +1 more source

Comparative histological study on the possible protective effect of Mitoquinone versus Oxymatrine on cerebellar cortex of adult male albino rats treated with Sofosbuvir [PDF]

The Egyptian Journal of Histology
:Background: Chronic hepatitis C is worldwide public-health issue. It is considered main cause for liver-related morbidity and mortality. Sofosbuvir, a direct-acting antiviral drug has revolutionized HCV treatment with high success rate.
Mona Soliman, Rania Emara, Dalia Noya
doaj   +1 more source