Results 41 to 50 of about 12,862 (201)

Successful treatment of vertically acquired Hepatitis C in a child using direct‐acting antiviral therapy administered via gastrojejunal tube: A case report

JPGN Reports, EarlyView.
Abstract Hepatitis C virus (HCV) remains a significant global health burden, with vertical transmission being the primary route of infection in children. Direct‐acting antivirals (DAAs) have transformed HCV treatment in pediatrics, but limited data exist on their administration in medically complex children who are dependent on enteral tubes. We report
Connie Chen, Leah Gibson, James Squires
wiley   +1 more source

Improving access to direct acting antivirals via a multimodal integrated care program in an addiction medicine clinic

The American Journal on Addictions, Volume 35, Issue 4, Page 534-542, July 2026.
Abstract Background and Objectives Injection drug use is a driver of hepatitis C virus (HCV) transmission, thus integrating HCV care into addiction care is likely necessary for HCV elimination. Here we describe how we integrated HCV care into our addiction medicine (AM) clinic and evaluate its effect on HCV treatment.
Arya Zandvakili, Joseph Rattenni, James Burton, Lakshmi Guduguntla, Marcus Osman, Sayeh Sabbagh, Stephan Arndt, Ben Miskle, Quanhathai Kaewpoowat, Michael Ohl, Andrea Weber, Alison Lynch   +11 more
wiley   +1 more source

Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C [PDF]

, 2016
Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir.
Mitchell, Kisha A, Jakab, Simona, Oikonomou, Ioannis, Lim, Joseph K, Sarkar, Souvik   +4 more
core   +1 more source

Revisiting Hydrazine Moiety as a Scaffold for the Synthesis of Potential Antiviral Pyrazole Ribonucleoside Analogues

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Three series of pyrazole ribonucleoside analogues were designed and synthesized. They were evaluated, along with some of their pronucleotides, for their antiviral activity against RNA viruses. Pyrazole ribonucleoside analogues were prepared via a linear approach starting with the reaction of D‐ribosylhydrazine with 1,3‐dicarbonyl or acrylonitrile ...
Anaïs Guillou, Nathalie Gros, Delphine Muriaux, Suzanne Peyrottes, Jean‐Jacques Vasseur, Michael Smietana, Christophe Mathé   +6 more
wiley   +1 more source

DIRECT ACTING ANTIVIRAL TREATMENT FOR PATIENTS WITH END STAGE KIDNEY DISEASE WITH ACUTE HCV INFECTION

Mediterranean Journal of Hematology and Infectious Diseases, 2019
Background: Hepatitis C virus (HCV) infection is a public health problem. Such an infection is prevalent and aggressive in patients with end-stage kidney disease (ESKD).
Nawfal R Hussein, Zana Saleem, Kais Abd
doaj   +1 more source

Patients with Hepatitis C Undergoing Direct-Acting Antiviral Treatment Have a Lower SARS-CoV-2 Infection Rate

Life, 2023
This study retrospectively analyzed the medical records of 602 patients with first-time positive results for the HCV nucleic acid test between 1 May 2021 and 31 March 2023, exploring the association between DAA treatment and SARS-CoV-2 infection.
Chin-Wen Hsu, Wan-Wen Yang, Chia-Yi Hou, I-Jung Feng, Ting-Yi Huang, Pei-Lun Lee, How-Ran Guo, Chien-Yuan Huang, Shih-Bin Su   +8 more
doaj   +1 more source

Efficacy and Safety of Adding Ribavirin to Sofosbuvir-Based Direct-Acting Antivirals (DAAs) in Re-Treating Non-Genotype 1 Hepatitis C—A Systematic Review and Meta-Analysis

Diseases
Background: There is still debate whether ribavirin should be added to direct-acting antivirals (DAAs) for the management of treatment-experienced individuals with non-genotype-1 hepatitis C.
Shahd Hamran, Amani A. Al-Rajhi, Kawthar Jasim, Majed A. Al-Theyab, Mohamed Elahtam, Mooza K. Al-Hail, Wadha Al-Fahaidi, Yaman A. Khamis, Yara Dweidri, Abdel-Naser Elzouki, Tawanda Chivese   +10 more
doaj   +1 more source

Stereoselective Production of Fluorohydrins Biocatalyzed by an Alcohol Dehydrogenase From Pichia glucozyma

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
Ketoreductase from Pichia glucozyma (KRED1‐Pglu) has been successfully employed for the stereoselective bioreduction of α‐halogenated ketones using the purified protein, or alternatively a lyophilized whole cell preparation overexpressed in E. coli. Better chemoselectivities were found with pure biocatalyst, obtaining a series of chiral fluorohydrins ...
Marina García‐Ramos, Iván Lavandera, Francesco Molinari, Martina Letizia Contente, Vicente Gotor‐Fernández   +4 more
wiley   +1 more source

Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis

, 2015
As the population that is infected with the hepatitis C virus (HCV) ages, the number of patients with decompensated cirrhosis is expected to increase.
Doehle, Brian, Schiff, Eugene, Fried, Michael, Bzowej, Natalie, An, Di, Curry, Michael P, Teperman, Lewis, Flamm, Steven L, McHutchison, John G, O'Leary, Jacqueline G, Fontana, Robert, Brown, Jr, Robert S, Fenkel, Jonathan M, Schiano, Thomas, Brainard, Diana M, Lawitz, Eric, ASTRAL-4 Investigators, Muir, Andrew J, Korenblat, Kevin M, McNally, John, Reddy, K Rajender, Osinusi, Anu, Charlton, Michael   +22 more
core   +1 more source

Cell-line dependent antiviral activity of sofosbuvir against Zika virus [PDF]

, 2017
The recent epidemic of Zika virus (ZIKV) in the Americas and its association with fetal and neurological complications has shown the need to develop a treatment.
Mumtaz, N. (Noreen), Bushman, L.R. (Lane R.), Kampen, J.J.A. (Jeroen) van, Aron, G.I. (Georgina), Kiser, J.J. (Jennifer J.), Reusken, C.B.E.M. (Chantal), Koopmans D.V.M., M.P.G. (Marion), Jimmerson, L.C. (Leah C.)   +7 more
core   +1 more source