Results 41 to 50 of about 121,021 (313)

Endothelial Cells Angiogenesis in Sulfated Glycosaminoglycan (GAG) Hydrogels Enhanced by Bioactive Glass‐Released Ions

Advanced Functional Materials, EarlyView.
A mechanically tunable hydrogel composed of gelatin, chondroitin sulfate and laminin promotes angiogenesis in vitro without the supplement of growth factors. Endothelial cells morphogenesis was further enhanced by medium conditioned with bioactive glass 58S‐released ions (Ca and Si), thus offering a promising strategy to vascularize 3D tissue ...
Marco Piazzoni, Ilaria Borghi, Francesca Cadamuro, Sophia Dalfino, Riccardo Campanile, Sofia Nizzolo, Valeria Cassina, Francesca Tallia, Julian R. Jones, Francesco Mantegazza, Sabrina Bertini, Lorenzo Moroni, Francesco Nicotra, Laura Russo   +13 more
wiley   +1 more source

Systemic inflammation index is a predictive and prognostic factor in patients with liposarcoma or leiomyosarcoma treated with trabectedin

Scientific Reports
Trabectedin is a chemotherapeutic agent that has shown activity in the treatment of patients with soft tissue sarcomas after failure of anthracycline-based therapy and the best results were recorded in the treatment of L-sarcomas.
Pawel Sobczuk, Paulina Filipowicz, Lukasz Lamparski, Hanna Kosela-Paterczyk, Pawel Teterycz, Katarzyna Kozak, Paweł Rogala, Tomasz Świtaj, Sławomir Falkowski, Piotr Rutkowski   +9 more
doaj   +1 more source

Lymphadenectomy in the treatment of sarcomas – indications and technique

Oncology Reviews
Sarcomas are a rare type of malignancy with limited treatment options so far. This analysis aimed to describe the impact of lymphadenectomy on treating sarcoma patients. Sarcomas characterized by lymphatic spread are rare.
Piotr Dunaj, Piotr Dunaj, Ewa Żukowska, Ewa Żukowska, Anna M. Czarnecka, Maria Krotewicz, Aneta Borkowska, Paulina Chmiel, Paulina Chmiel, Tomasz Świtaj, Piotr Rutkowski   +10 more
doaj   +1 more source

iCREATE: imaging features of primary and metastatic alveolar soft part sarcoma from the EORTC CREATE study

Cancer Imaging, 2020
Background Alveolar Soft Part Sarcoma (ASPS) is a rare, slow-growing, but highly vascular soft tissue sarcoma, characterised by a high rate of metastases at presentation.
Naami Charlotte Mcaddy, Hind Saffar, Saskia Litière, Pieter Jespers, Patrick Schöffski, Christina Messiou   +5 more
doaj   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Efficacy of radiotherapy and radiotherapy with hyperthermia to delay change of systemic therapy in patients with metastatic melanoma

Clinical and Translational Radiation Oncology
Background: The use of radiotherapy (RT) and RT with hyperthermia (HT) as a local treatment for oligoprogression in many tumors is becoming increasingly prevalent.
Paulina Chmiel, Mateusz Jacek Spałek, Hanna Koseła-Paterczyk, Piotr Łukasz Rutkowski, Paulina Jagodzińska-Mucha, Paweł Rogala, Katarzyna Kozak, Maria Telejko, Aneta Maria Borkowska   +8 more
doaj   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

From pathogenesis to the patient’s bedside: a comprehensive review of extraskeletal myxoid chondrosarcoma

Journal of Cancer Research and Clinical Oncology
Extraskeletal myxoid chondrosarcoma (EMC) is characterised by recurrent NR4A3 gene rearrangements, most commonly EWSR1::NR4A3, and accounts for approximately 1–3% of soft-tissue sarcomas (STS). It typically arises in the deep soft tissues of the proximal
Piotr Remiszewski, Sławomir Falkowski, Anna Szumera-Ciećkiewicz, Mateusz J. Spałek, Piotr Rutkowski, Anna M. Czarnecka   +5 more
doaj   +1 more source

Molecular and Clinicopathological Biomarkers in the Neoadjuvant Treatment of Patients with Advanced Resectable Melanoma

Biomedicines
Neoadjuvant systemic therapy is emerging as the best medical practice in patients with resectable stage III melanoma. As different regimens are expected to become available in this approach, the improved optimization of treatment strategies is required ...
Piotr J. Błoński, Anna M. Czarnecka, Krzysztof Ostaszewski, Anna Szumera-Ciećkiewicz, Piotr Rutkowski   +4 more
doaj   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source