Results 71 to 80 of about 12,672,734 (314)
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Software for Schenkerian Analysis [PDF]
, 2011 Software developed to automate the process of Schen-kerian analysis is described. The current state of the art is that moderately good analyses of small extracts can be generated, but more information is required about the criteria by which analysts make
Marsden, Alan
core +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Software Processes Are Software Too, Revisited [PDF]
Proceedings of the 19th international conference on Software engineering - ICSE '97, 1997 The ICSE 9 paper, “Software Processes are Software Too”’ suggests that software processes are themselves a form of software and that there are considerable benefits that will derive from basing a discipline of software process development on the more traditional discipline of application software development.
openaire +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2005 Este trabalho corresponde à segunda parte de uma publicação sobre o comportamento estrutural de vigas de concreto reforçadas com bambu, na qual se apresenta e discute a modelagem dessas estruturas para, em seguida, serem apresentadas sugestões e ...
Humberto C. Lima Júnior +2 more
doaj +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Software Corrections of Vocal Disorders
, 2001 We discuss how vocal disorders can be post-corrected via a simple nonlinear noise reduction scheme. This work is motivated by the need of a better understanding of voice dysfunctions.
Manfredi, Claudia, Matassini, Lorenzo
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Maleku: an evolutionary visual software analytics tool for providing insights into software evolution [PDF]
, 2011 Software maintenance is a complex process that requires the understanding and comprehension of software project details. It involves the understanding of the evolution of the software project, hundreds of software components and the relationships among ...
García-Peñalvo, Francisco +4 more
core