Results 51 to 60 of about 430,233 (296)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Matlab code and datasets for: Mathematical recapitulation of the end stages of human ovarian aging
, 2023 Mathematical recapitulation of the end stages of human ovarian agingThe existing criteria used to define menopause and the menopausal transition (MT) are consequences of altered signaling within the hypothalamus-pituitary-ovarian (HPO) axis, but ...
Joshua Johnson (7365485) +1 more
core +1 more source
Availability Analysis and Improvement of Software Rejuvenation Using Virtualization [PDF]
Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2007 Availability of business-critical application servers is an issue ofparamount importance that has received special attention from the industry and academia.
Jong Sou PARK +2 more
doaj
IEEE Access, 2019 Most companies and organizations rely nowadays on virtualized environments to host and run their applications. Some of these applications have stringent availability and security requirements.
Matheus Torquato +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Software aging and rejuvenation in the cloud: a literature review
, 2018 —With cloud computing becoming pervasive in IT enterprises, the long-running performance of cloud-based applications and services and of the underlying virtualization systems is a paramount concern.
Roberto Pietrantuono, Stefano Russo
core +1 more source
On Software Ageing Indicators in OpenStack
CoRRDistributed systems in general and cloud systems in particular, are susceptible to failures that can lead to substantial economic and data losses, security breaches, and even potential threats to human safety. Software ageing is an example of one such vulnerability.
Yevhen Yazvinskyi +3 more
openaire +2 more sources
A methodology for detection and estimation of software aging [PDF]
Proceedings Ninth International Symposium on Software Reliability Engineering (Cat. No.98TB100257), 2002 The phenomenon of software aging refers to the accumulation of errors during the execution of the software which eventually results in it's crash/hang failure. A gradual performance degradation may also accompany software aging. Pro-active fault management techniques such as "software rejuvenation" (Y.
Sachin Garg +3 more
openaire +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
A Tutorial on Cognitive Modeling for Cognitive Aging Research
, 2021 Cognitive aging researchers are interested in understanding how cognitive processes change in old age, but the standard analyses used on observed behavior (e.g., ANOVA) are inappropriate for measuring age differences in latent cognitive processes ...
Stephen Rhodes, Nathaniel R. Greene
core +1 more source