Results 61 to 70 of about 430,233 (296)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Software Licensing in the Cloud Age
CoRR, 2014 Cloud computing represents a major shift in information systems architecture, combining both new deployment models and new business models. Rapid provisioning, elastic scaling, and metered usage are essential characteristics of cloud services, and they require cloud resources with these same characteristics.
openaire +2 more sources
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
An analysis of software aging in cloud environment
, 2020 Cloud Computing is the environment in which several virtual machines (VM) run concurrently on physical machines. The cloud computing infrastructure hosts multiple cloud service segments that communicate with each other using the interfaces.
P., Shruthi +3 more
core +1 more source
Analysis of Gene Evolution: the software AGE [PDF]
Bioinformatics, 1992 The software AGE (Analysis of Gene Evolution) has been developed both to study a genetic reality, i.e. the identification of statistical properties in genes (e.g. periodicities), and to simulate this observed genetic reality, by models of molecular evolution.
Didier Arquès +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
SAR Handbook Chapter: Measurements-based aging analysis
, 2020 This paper summarizes the main methods adopted for the analysis and detection of software aging phenomena based on measurements (measurements-based aging analysis) as well as the metrics more commonly used as aging ...
Alonso J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
MedCSS: a causal self-supervised approach for hierarchical feature consistency in 3D medical imaging
Frontiers in NeuroscienceMedical image analysis plays a crucial role in linking perceptual mechanisms with clinical diagnosis, yet conventional deep learning models often rely on statistical correlations rather than modeling the underlying generative structure, leading to ...
Jiang Han +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source