Results 61 to 70 of about 444,537 (260)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Retrofitting enables sustainability, Industry 4.0 connectivity, and improved usability
Advances in Industrial and Manufacturing EngineeringRetrofitting is a sustainable approach to improving the capabilities and extending the life of aging machine tools. Reusing the mechanical construction and replacing only the control electronics and software is a viable option to upgrade an aging machine
Tero Kaarlela +3 more
doaj +1 more source
Aging of Black Women: Reflections Based on Listening to Their Protagonists [PDF]
Psicologia: Teoria e PesquisaStudying the older, black, and female population implies the need to understand their experiences, as aging is not a universally uniform process. This article aims to investigate the social representations constructed by older black women, residents of ...
Polliana Teixeira da Silva +1 more
doaj +4 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Measuring Anti-aging Effects in Drosophila
Bio-ProtocolOne of the major factors contributing to aging and age-related diseases is the well-understood decline in the function of adult stem cells. Quantifying the degree of aging in adult stem cells is essential for advancing anti-aging mechanisms and ...
Hyun-Jin Na, Joung-Sun Park
doaj +1 more source
Aging embrittlement at high temperature of 9Cr3W3Co steel and its improvement method
Cailiao gongcheng, 2019 The main factor that results in aging embrittlement of 9Cr3W3Co steel was investigated through microstructure observation using scanning electron microscopy (SEM). The amount of each precipitates under equilibrium state in 9Cr3W3Co steel with different W
MA Long-teng, LIU Zheng-dong, BAI Yin
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
ElectricitySoftware aging and the corresponding need for system rejuvenation are well-established concepts in computer science. As virtualization technologies are increasingly adopted within electric power utility infrastructures, early investigation into Software ...
Rizwan Rafique Syed +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source