Results 81 to 90 of about 430,233 (296)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Software Ageing and Rejuvenation: Where We Are and Where We Are Going

, 2011
After 16 years, a significant body of knowledge has been established in the area of Software Aging and Rejuvenation (SAR). In this paper, we survey papers about SAR that appeared in IEEE conferences and journals, identify where SAR research has been ...
COTRONEO, DOMENICO, NATELLA, ROBERTO, Domenico Cotroneo, PIETRANTUONO, ROBERTO, Roberto Pietrantuono, RUSSO, STEFANO, Roberto Natella, Stefano Russo   +7 more
core   +1 more source

Software Aging Forecasting Using Time Series Model

, 2017
With the emergence of virtualization and cloud computing technologies, several services are housed on virtualization platform. Virtualization is the technology that many cloud service providers rely on for efficient management and coordination of the ...
I. M. Umesh, Srinivasan, G N, Torquato, Matheus, G. N. Srinivasan, Matheus Torquato, Umesh, I M   +5 more
core   +3 more sources

Aging embrittlement at high temperature of 9Cr3W3Co steel and its improvement method

Cailiao gongcheng, 2019
The main factor that results in aging embrittlement of 9Cr3W3Co steel was investigated through microstructure observation using scanning electron microscopy (SEM). The amount of each precipitates under equilibrium state in 9Cr3W3Co steel with different W
MA Long-teng, LIU Zheng-dong, BAI Yin
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Software aging prediction – a new approach

, 2023
To meet the users’ requirements which are very diverse in recent days, computing infrastructure has become complex. An example of one such infrastructure is a cloud-based system.
Parashivamurthy, Shruthi, Nagaraj Girish Cholli, Shruthi Parashivamurthy, Cholli, Nagaraj Girish   +3 more
core   +1 more source

Measuring Anti-aging Effects in Drosophila

Bio-Protocol
One of the major factors contributing to aging and age-related diseases is the well-understood decline in the function of adult stem cells. Quantifying the degree of aging in adult stem cells is essential for advancing anti-aging mechanisms and ...
Hyun-Jin Na, Joung-Sun Park
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Availability Improvement in Software Aging Applications [PDF]

, 2009
With the explosive growth in Internet technology and the emergence of new and advanced applications, assured availability of computer systems has become a critical issue.
Myint, May Tar Hla, Thein, Thandar
core