Results 71 to 80 of about 430,233 (296)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Analysis of Software Aging in a Web Server [PDF]
A number of recent studies have reported the phenomenon of “software aging”, characterized by progressive performance degradation and/or an increased occurrence rate of hang/crash failures of a software system due to the exhaustion of operating system ...
Liz, Lei +3 more
core
JMIR AgingBackgroundGlobally, various aging concepts (such as healthy aging, successful aging, and active aging) have emerged to promote the goal of “aging well” and have gained widespread attention in academia, policy, and practice to change the negative ...
Na Xiao +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Aging of Black Women: Reflections Based on Listening to Their Protagonists [PDF]
Psicologia: Teoria e PesquisaStudying the older, black, and female population implies the need to understand their experiences, as aging is not a universally uniform process. This article aims to investigate the social representations constructed by older black women, residents of ...
Polliana Teixeira da Silva +1 more
doaj +4 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Population Aging in Canada: Software for Exploring the Implications for the Labour Force and the Productive Capacity of the Economy [PDF]
This report has two purposes: (1) to introduce a new version of the MEDS (Models of the Economic Demographic System) software; and (2) to apply it in a series of illustrative projections.
Byron G. Spencer +2 more
core +2 more sources
Investigating Software Aging in LLM-Generated Software Systems
2025 IEEE 36th International Symposium on Software Reliability Engineering Workshops (ISSREW)Automatically generated software, especially code produced by Large Language Models (LLMs), is increasingly adopted to accelerate development and reduce manual effort. However, little is known about the long-term reliability of such systems under sustained execution.
César Santos +2 more
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Retrofitting enables sustainability, Industry 4.0 connectivity, and improved usability
Advances in Industrial and Manufacturing EngineeringRetrofitting is a sustainable approach to improving the capabilities and extending the life of aging machine tools. Reusing the mechanical construction and replacing only the control electronics and software is a viable option to upgrade an aging machine
Tero Kaarlela +3 more
doaj +1 more source