Results 101 to 110 of about 1,521,635 (308)

Integration of Extra-Functional Properties in Component Models

, 2009
Management of extra-functional properties in component models is one ofthe main challenges in the component-based software engineering community.Still, the starting point in their management, namely their specification in acontext of component models is ...
Ivica Crnković, Petr Štěpán, Crnkovic, Ivica,, Stepan, Petr,, Carlson, Jan,, Séverine Sentilles, Sentilles, Séverine,, Jan Carlson   +7 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Evolution of a Software Component -- Experiences with a Network Editor

, 2003
Even though the benefits of component-based software development are widely accepted, they are easily overestimated. To provide a firmer basis for the general discussion we describe our real life experiences with a software component.
Component Jyrki Akkanen, Jyrki Akkanen
core  

Design Patterns and Component Framework for Building RTSJ-Based Real-Time Middleware [PDF]

, 2010
The middleware is a software layer located on top of the operating system that uses its facilities, integrates with it, and extends its functionality in order to support the development of effective and reliable distributed systems; however, the ...
Alrahmawy, Mohammed
core  

Using autonomous components to improve runtime qualities of software

, 2011
In the development of software systems, quality properties should be considered along with the development process so that the qualities of software systems can be inferred and predicted at the specification and design stages and be evaluated and ...
Jiao, W., W. Jiao
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Genetic Algorithm for Automated Refactoring of Component-Based Software

EAI Endorsed Transactions on Creative Technologies, 2016
Nowadays a software undergoes modifications done by different people to quickly fulfill new requirements, but its underlying design is not adjusted properly after each update. This leads to the emergence of bad smells.
Salim Kebir, Isabelle Borne, Djamel Meslati   +2 more
doaj   +1 more source

Applications of Multi-view Learning Approaches for Software Comprehension

, 2019
Program comprehension concerns the ability of an individual to make an understanding of an existing software system to extend or transform it. Software systems comprise of data that are noisy and missing, which makes program understanding even more ...
Khadka, Ravi, Jansen, Slinger, Saeidi, Amir, Organization and Information, Sub Organization and Information, Software Technology, Hage, Jurriaan; id_orcid, Hage, Jurriaan, Sub Software Technology, Sub Algemeen Software Systems   +9 more
core   +1 more source