Results 121 to 130 of about 1,521,635 (308)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Research Article Software Component Selection Based on Quality Criteria Using the Analytic Network Process

, 2014
Component based software development (CBSD) endeavors to deliver cost-effective and quality software systems through the selection and integration of commercially available software components.
Nazir, Shah, Ali, Muhammad, Shahzad, Sara, Amin, Rohul, Cosmas, John, Lazaridis, Pavlos, Anwar, Sajid, Sher Afzal, Khan, Nawaz, Muhammad   +8 more
core  

Transforming Platform-Independent to Platform-Specific Component and Connector Software Architecture Models

, 2022
3035Combining component & connector architecture description languages with component behavior modeling languages enables modeling great parts of software architectures platform independently.
Rumpe, B., Ringert, J.O., Wortmann, A.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

BAREMO: How to Choose the Appropriate Software Component Using the Analytic Hierarchy Process

, 2002
To select a software component from several similar candidates is a complex task, since each project pursues different objectives. We intend to use the Analytic Hierarchy Process in the taking of multicriteria decisions for software component reuse. This
Lozano-Tello, A., Gómez-Pérez, A.
core  

Component-Based Software Engineering. The KobrA Approach

, 2022
S.247-252 : Ill., Lit.The software industry is pinning its hopes for future software productivity and quality gains on component-based development. However, to date the component paradigm has only really penetrated the "implementation" phase of the ...
Bunse, C., Bayer, J., Muthig, D., Kamsties, E., Wüst, J., Zettel, J., Laitenberger, O., Laqua, R., Atkinson, C., Paech, B.   +9 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hardware/software Co-synthesis for SoC Design

工程科学与技术, 2006
:Embedded systems are composed of hardware and software. Many functions of the systems can be realized by either software or hardware. In order to partition the system according to function and performance requirements, such as cost, size, power ...
doaj  

Component Software:

, 2003
In recent years component-based software development has emerged as an important new set of methods and technologies. This paper describes a new course---Component Software---that focuses on componentbased design using technology-independent methods ...
H. Conrad Cunningham, Mingxian Fu, New Software Engineering, Pallavi Tadepalli, Yi Liu   +4 more
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