Results 141 to 150 of about 1,521,635 (308)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Delayed failure of software components using stochastic testing [PDF]

, 2012
The present research investigates the delayed failure of software components and addresses the problem that the conventional approach to software testing is unlikely to reveal this type of failure. Delayed failure is defined as a failure that occurs some
Gardiner, Jeremy
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Component-Oriented Programming for Embedded Mobile Robot Software

International Journal of Advanced Robotic Systems, 2008
Applying software reuse to many Embedded Real-Time (ERT) systems poses significant challenges to industrial software processes due to the resource-constrained and real-time requirements of the systems.
Safaai Deris, Dayang N. A. Jawawi, Rosbi Mamat   +2 more
doaj  

Model driven, component-based development

, 2022
S.27-48 : Ill., Lit.As complex behavioral abstractions, business components in many ways can be viewed as (sub)systems in their own right, and thus need to be treated as such.
Groß, H.-G., Atkinson, C.
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Organising the knowledge space for software components [PDF]

, 2005
Software development has become a distributed, collaborative process based on the assembly of off-the-shelf and purpose-built components. The selection of software components from component repositories and the development of components for these ...
Pahl, Claus
core  

A globally-applied component model for programmable networking

, 2003
We argue that currently developed software frameworks for active and programmable networking do not provide a truly generic approach to the development, deployment, and management of services.
Kevin Lee, Blair, Gordon, Lee, K, Blair, GS, Blair, G.S., Gomes, A.T., Schmid, S, Joolia, A, Ackbar Joolia, J ó Ueyama, Geoff Coulson, Schmid, S., Lee, K., Stefan Schmid, Antônio T. Gomes, Gomes, A T, Joolia, A., Gordon S. Blair, Coulson, G., Ueyama, J., Gomes, AT, Ueyama, J, Coulson, G   +22 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Semantic Integrity in Component Based Development

, 2002
Due to the distributed nature of the growing field of Component Based Software Engineering (CBSE) and the increasing complexity of modern systems, the semantic aspects of software components must be well specified.
Blom, Martin,, Nordby, Eivind J,
core