Results 131 to 140 of about 1,521,635 (308)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Adopting a component-based software architecture for an industrial control system - A case study
, 2005 This chapter presents a case study from a global company developing a new generation of programmable controllers to replace several existing products.
Crnkovic, I +8 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Software Components, Architectures and Reuse. [PDF]
J. Univers. Comput. Sci., 2011 Software Components, Architectures and ...
Pires,Paulo +2 more
openaire +2 more sources
A domain-specific language based approach to component composition, error-detection, and fault prediction [PDF]
, 2001 Current methods of software production are resource-intensive and often require a number of highly skilled professionals. To develop a well-designed and effectively implemented system requires a large investment of resources, often numbering into ...
Ingham, James, Ingham, J.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Component-Oriented Software Technology
, 1995 Modern software systems are increasingly required to be open and distributed. Such systems are open not only in terms of network connections and interoperability support for heterogeneous hardware and software platforms, but, above all, in terms of ...
Nierstrasz, Oscar, Dami, Laurent
core
Using real options to select stable Middleware-induced software architectures
, 2005 The requirements that force decisions towards building distributed system architectures are usually of a non-functional nature. Scalability, openness, heterogeneity, and fault-tolerance are examples of such non-functional requirements.
W. Emmerich +5 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Component-Based Software Engineering in Pervasive Computing Environments
, 2018 Being able to find, adapt, and incorporate disparate components to form working, reliable applications is the goal of component-based software engineering.
David Garlan (5359970) +1 more
core +1 more source