Results 121 to 130 of about 21,707,590 (377)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Variability-Aware Machine Learning Model Selection: Feature Modeling, Instantiation, and Experimental Case Study

open access: yesIEEE Access
The emergence of machine learning (ML) has led to a transformative shift in software techniques and guidelines for building software applications that support data analysis process activities such as data ingestion, modeling, and deployment. Specifically,
Cristina Tavares   +3 more
doaj   +1 more source

Software engineering and Ada in design [PDF]

open access: yes
Modern software engineering promises significant reductions in software costs and improvements in software quality. The Ada language is the focus for these software methodology and tool improvements.
Oneill, Don
core   +1 more source

Autonomous Boat Control Software Design Using Model-Based Systems Engineering [PDF]

open access: yes, 2019
While there is considerable buzz about self-driving cars, self-driving boats are actually more fully developed. The Boat Hardware Control Platform Team was tasked with developing a fleet of small autonomous boats that travel to a destination while ...
Nelson, Noah
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Data Comparison and Software Design for Easy Selection and Application of CRISPR-based Genome Editing Systems in Plants. [PDF]

open access: yesGenomics Proteomics Bioinformatics, 2021
Wang Y   +6 more
europepmc   +1 more source

Working Notes from the 1992 AAAI Workshop on Automating Software Design. Theme: Domain Specific Software Design [PDF]

open access: yes
The goal of this workshop is to identify different architectural approaches to building domain-specific software design systems and to explore issues unique to domain-specific (vs. general-purpose) software design. Some general issues that cut across the
Barstow, David   +3 more
core   +1 more source

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