Results 121 to 130 of about 876,988 (310)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Framework for the Definiton of a Generative Design Pattern
Conventional design patterns found in many pattern catalogues are static components of reusable design knowledge. They are fully descriptive of the problems they will solve, but the descriptive knowledge and design they provide does not describe how they
Wilson, David
core
An overview of human-computer interaction patterns in pervasive systems
, 2010 Despite a growing interest in design patterns by the Human-Computer Interaction (HCI) community, an interaction pattern collection that is universally accepted is yet to be found.
Wilde, Adriana +6 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Modularity Improvement of Design Patterns
Design patterns are known as proven solutions for solving frequently occurring problems in software development. Unfortunately, they do not fully correspond to modularity principles, and their implementations are usually not considered to be reusable ...
Kotovs, Vladimirs
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Improving the Design and Implementation of Software Systems uses Aspect Oriented Programming
A design pattern is used as a static reusable component of object oriented design in the many patterns catalogue. The regular design pattern does not show any collaboration of shared resource between patterns in the software design. But generative design
Ghareb, Mazen +2 more
core
Towards Modeling Patterns for Embedded Software Industry: Feedback From the Field
, 2018 Akdur, Deniz/0000-0001-8966-2649; Say, Bilge/0000-0001-9276-729X; Demirors, Onur/0000-0001-6601-3937The analysis, design, implementation and testing of software for embedded systems are not trivial.
Demirors, Onur, Say, Bilge, Akdur, Deniz
core +1 more source