Results 111 to 120 of about 14,948,240 (284)
Modularity Improvement of Design Patterns
Design patterns are known as proven solutions for solving frequently occurring problems in software development. Unfortunately, they do not fully correspond to modularity principles, and their implementations are usually not considered to be reusable ...
Kotovs, Vladimirs
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Redocumentation through design pattern recovery:: an investigation and an implementation [PDF]
, 2001 In this thesis, two methods are developed in an aid to help users capture valuable design information and knowledge and reuse them. They are the design pattern recovery (DPR) method and pattern-based redocumentation (PBR) method.
Hyoseob, Kim
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Applying Scrum and Organizational Patterns to Multi-site Software Development
, 2007 This paper describes a pattern language for managing multi-site software projects which aims at minimizing the main problems present on the multi-site software development context. The practices and patterns of the proposed language were first identified
Cordeiro, Lucas +2 more
core +1 more source
Design Patterns for Software Sustainability
Proceedings of the 31st Conference on Pattern Languages of Programs, People, and PracticesThis is the dataset for our paper "Design Patterns for Software Sustainability"
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Context Is All You Need: A Hybrid Attention-Based Method for Detecting Code Design Patterns
IEEE AccessSoftware reverse engineering plays a crucial role in identifying design patterns and reconstructing software architectures by analyzing system implementations and producing abstract representations across multiple layers. This research introduces a novel
Tarik Houichime, Younes El Amrani
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Modeling Patterns in Software Design
, 2007 Software patterns provide solutions to recurring design problems, provide a way to reason about the quality attributes, and support stakeholders in understanding the system. Naturally, the use of software patterns emerges from the requirements of the software. Use Cases have been a traditional and authentic approach to document these requirements.
Waqas, Ahmad, Kamal, Fawad
openaire +2 more sources