Results 91 to 100 of about 876,988 (310)
A Blockchain Approach to Extract Design Patterns From Source Codes
Modelling and Simulation in EngineeringDesign patterns are an effective technique for software development. However, lacking suitable documents often reduces traceability, and advantages remain unclear in source lines of code (SLOC).
Shahla Rezaei +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Business model driven service architecture design for enterprise application integration [PDF]
, 2008 Increasingly, organisations are using Service-Oriented Architecture (SOA) as an approach to Enterprise Application Integration (EAI), which is required for the automation of business processes.
Claus Pahl +5 more
core
On the Impact of Aspectual Decompositions on Design Stability: An Empirical Study. [PDF]
, 2007 . Although one of the main promises of aspect-oriented (AO) programming techniques is to promote better software changeability than object-oriented (OO) techniques, there is no empirical evidence on their efficacy to prolong design stability in realistic
Borba, P +31 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Component-based tool for verifying applications using object-oriented patterns
Journal of Computer Science and Technology, 2002 Applying design patterns is considered a helpful technique for designing software systems. Patterns description, however, results not sufficiently precise providing a weak understanding and making it difficult to be certain when a pattern is being used ...
Luis A. Reynoso +3 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Dark Patterns in the Design of Games [PDF]
, 2013 Game designers are typically regarded as advocates for players. However, a game creator’s interests may not align with the players’. We examine some of the ways in which those opposed interests can manifest in a game’s design.
Zagal, José P +4 more
core
Accessibility and adaptability of learning objects: responding to metadata, learning patterns and profiles of needs and preferences [PDF]
, 2006 The case for learning patterns as a design method for accessible and adaptable learning objects is explored. Patterns and templates for the design of learning objects can be derived from successful existing learning resources.
Green, Steve +7 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source