Results 41 to 50 of about 876,988 (310)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Design Patterns for Wrapping Similar Legacy Systems with Common Service Interfaces
, 2006 Web Services are increasingly being used to create a wide range of distributed systems, many of which involve legacy software. Developing service interfaces for these legacy systems can be difficult, as for interoperability reasons it is advantageous to ...
Lester Gilbert +13 more
core +1 more source
SensorsCurrently, people spend a lot of time using their mobile devices. With such ubiquity of mobile devices in our daily life, battery capacity and quality are of utmost importance.
Claudiu Groza +3 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A Secure Auditable Remote Registry Pattern for IoT Systems
Future InternetIn software engineering, pattern papers serve the purpose of providing a description of a generalized, reusable solution to recurring design problems, based on practical experience and established best practices.
Antonio Maña +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
APPLICATION OF EVENT SOURCING AND CQRS PATTERNS IN DISTRIBUTED SYSTEMS
Adaptivni Sistemi Avtomatičnogo Upravlinnâ, 2019 The purpose of this report is finding suitable approaches for dealing with the issue, particularly ability to recreate system state in modern high load distributed systems. In order to achieve the goal, the report will overview existing problems, compare
Serhii Diakov +2 more
doaj +1 more source
Empirical study of the relationship between design patterns and code smells.
PLoS ONE, 2020 Software systems are often developed in such a way that good practices in the object-oriented paradigm are not met, causing the occurrence of specific disharmonies which are sometimes called code smells.
Mahmoud Alfadel +2 more
doaj +1 more source
Architecture and Architectural Patterns for Mobile Augmented Reality
South African Computer Journal, 2021 A software architecture codifies the design choices of software developers, which defines a modular organizational spine for the design of a software artefact.
Donald Munro, Andre Calitz, Dieter Vogts
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source