Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Pattern-based software architecture for service-oriented software systems [PDF]
, 2010 Service-oriented architecture is a recent conceptual framework for service-oriented software platforms. Architectures are of great importance for the evolution of software systems.
Pahl, Claus, Barrett, Ronan
core
A Framework for Patterns in Gaia: A case-study with Organisations
, 2004 The agent-oriented approach has been successfully applied to the solution of complex problems in dynamic open environments. However, to extend its use to mainstream computing and industrial environments, appropriate software tools are needed.
Luck, Michael +4 more
core +1 more source
Using Design Patterns in Education and Tutoring for the Software Systems Projects in Economic [PDF]
Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2009 The paper deals with a training system with a client-serverarchitecture created for students who are learning to design and implementobject-oriented software systems with reusable components, and also targetingthose users who wish become accustomed with (
Cornelia NOVAC-UDUDEC
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Design patterns for automation of marketing authorisations in pharmaceutical industry [PDF]
, 2005 This paper reports on the experiences of using existing and creating new design patterns when deploying layered and component based software architecture that automates procedures for marketing authorization.
Milligan, P. +5 more
core +1 more source
A C++ Design for Self-Registering Objective Functions in Optimization Frameworks
The PinnacleThis article presents a robust, modern C++ design pattern for managing objective functions within optimization frameworks. This design introduces a self-registration mechanism that automatically registers new objective functions at compile-time.
Mikal Keenan
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Design Patterns and Component Framework for Building RTSJ-Based Real-Time Middleware [PDF]
, 2010 The middleware is a software layer located on top of the operating system that uses its facilities, integrates with it, and extends its functionality in order to support the development of effective and reliable distributed systems; however, the ...
Alrahmawy, Mohammed
core
Identification and Assessment of Software Design Pattern Violations [PDF]
النشرة المعلوماتیة فی الحاسبات والمعلومات, 2019 The validation of design pattern implementations to identify pattern violations has gained more relevance as part of re-engineering processes in order to preserve, extend, reuse software projects in rapid development environments. If design pattern implementations do not conform to their definitions, they are considered a violation.
Tamer Abdelaziz +3 more
openaire +2 more sources