Results 61 to 70 of about 14,948,240 (284)

A C++ Design for Self-Registering Objective Functions in Optimization Frameworks

The Pinnacle
This article presents a robust, modern C++ design pattern for managing objective functions within optimization frameworks. This design introduces a self-registration mechanism that automatically registers new objective functions during static ...
Mikal Keenan
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Design Patterns for Wrapping Similar Legacy Systems with Common Service Interfaces

, 2006
Web Services are increasingly being used to create a wide range of distributed systems, many of which involve legacy software. Developing service interfaces for these legacy systems can be difficult, as for interoperability reasons it is advantageous to ...
Lester Gilbert, Howard, Yvonne, Davis, Hugh, Jam, Ehtesham-Rasheed, Hugh Davis, Wills, Gary, Yvonne Howard, Chennupati, Swapna, Ehtesham-rasheed Jam, David Millard, Millard, David, Gilbert, Lester, Swapna Chennupati, Gary Wills   +13 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Toward proactive eco-design based on engineer and eco-designer's software interface modeling [PDF]

, 2011
Lien vers la version éditeur: http://www.designsociety.org/publication/30585/toward_proactive_eco-design_based_on_engineer_and_eco-designers_software_interface_modelingIntegrating environmental concerns as well as other constrains (cost, quality, etc ...
RIO, Maud, REYES, Tatiana, ROUCOULES, Lionel   +2 more
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Design Pattern Detection by Using Meta Patterns [PDF]

, 2008
One of the approaches to improve program understanding is to extract what kinds of design pattern are used in existing object-oriented software. This paper proposes a technique for efficiently and accurately detecting occurrences of design patterns ...
KOBAYASHI, Takashi, SAEKI, Motoshi, KATADA, Junya, HAYASHI, Shinpei, SAKAMOTO, Ryota   +4 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Pattern-based software architecture for service-oriented software systems [PDF]

, 2010
Service-oriented architecture is a recent conceptual framework for service-oriented software platforms. Architectures are of great importance for the evolution of software systems.
Pahl, Claus, Barrett, Ronan
core   +2 more sources