Results 121 to 130 of about 6,815,566 (351)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Project Management - Software Development Methodology [PDF]

open access: yes
This article talks about project management in a software development area. The emphasis is given to the process of software development and the main responsibilities of the project manager.
Zvonimir Vukovic
core  

Learning Irregular Space Transformation for Person Re-Identification

open access: yesIEEE Access, 2018
Person re-identification (ReID) classifies the discriminative features of different people. Human perception usually depends on the minority of discriminative colors to classify targets, rather than the majority of mutual colors. ReID uses a small number
Yanwei Zheng   +5 more
doaj   +1 more source

Toward a Better Understanding of How to Develop Software Under Stress - Drafting the Lines for Future Research [PDF]

open access: yesarXiv, 2018
The software is often produced under significant time constraints. Our idea is to understand the effects of various software development practices on the performance of developers working in stressful environments, and identify the best operating conditions for software developed under stressful conditions collecting data through questionnaires, non ...
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Software development environment, appendix F [PDF]

open access: yes
The current status in the area of software development environments is assessed. The purposes of environments, the types of environments, the constituents of an environment, the issue of environment integration, and the problems which must be solved in ...
Riddle, W. E.
core   +1 more source

Effects of Sensor Location on Dynamic Load Estimation in Weigh-in-Motion System

open access: yesSensors, 2018
In recent years, weigh-in-motion systems based on embedded sensor networks have received a lot of attention. However, how to improve the accuracy of multi-sensor weigh-in-motion (WIM) systems while keeping costs low remains a challenge.
Tianhao Qin   +4 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

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