Results 71 to 80 of about 7,204,729 (322)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Teaching Software Development to Non-Software Engineering Students [PDF]
This paper argues that although the object-oriented programming (OOP) paradigm is appropriate for students taking programming modules on Higher Education (HE) software engineering course, this paradigm is not as relevant for students from other courses ...
Colvin, John
core
Distributed software development in a financial services organisation [PDF]
, 2008 The outsourcing of IS functionality to offshore development firms has been a growth industry that has blossomed over the last 10 years. This is as a result of organisations, seeking to optimise costs, mitigate risks, and achieve greater return on ...
Irani, Z, Sharif, A M
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Machine learning model for predicting cyber-criminal characteristics
Kuwait Journal of ScienceThis study aims to predict investigation outcomes of individual cybercrime cases using the most relevant information provided by complainants. We curated a dataset on solved hacking cases from 2019 to 2022 from the cyber-crime combating department (3CD ...
Hesham A. Almansouri +2 more
doaj +1 more source
BioRel: towards large-scale biomedical relation extraction
BMC Bioinformatics, 2020 Background Although biomedical publications and literature are growing rapidly, there still lacks structured knowledge that can be easily processed by computer programs.
Rui Xing, Jie Luo, Tengwei Song
doaj +1 more source
Automated software development workstation [PDF]
Engineering software development was automated using an expert system (rule-based) approach. The use of this technology offers benefits not available from current software development and maintenance methodologies.
core +1 more source
An ontology of agile aspect oriented software development [PDF]
, 2011 Both agile methods and aspect oriented programming (AOP) have emerged in recent years as new paradigms in software development. Both promise to free the process of building software systems from some of the constraints of more traditional approaches.
Parsons, David
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Software development: Stratosphere modeling [PDF]
A more comprehensive model for stratospheric chemistry and transport theory was developed for the purpose of aiding predictions of changes in the stratospheric ozone content as a consequence of natural and anthropogenic processes.
Chen, H. C.
core +1 more source