Results 71 to 80 of about 6,869,870 (334)
FEBS Letters, EarlyView.We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio +9 more
wiley +1 more source
Agile Software Development [PDF]
E-Learning and Digital Media, 2008 Many software development firms are now adopting the agile software development method. This method involves the customer at every level of software development, thus reducing the impact of change in the requirement at a later stage. In this article, the principles of the agile method for software development are explored and there is a focus on its ...
openaire +3 more sources
A MANAGED APPROACH OF INTERACTION BETWEEN AGILE SCRUM AND SOFTWARE CONFIGURATION MANAGEMENT SYSTEM [PDF]
, 2012 In current age the agile software development is one of the most popular software development methodology but due the mismanagement and lack of efficient handling of agile scrum and software configuration management system our software industry is facing
Parvez, Abu Wahid Md. Masud
core
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
ITM Web of Conferences, 2017 In response to extension of coverage goals in higher education, academic programs offering has been growing in regions geographically dispersed which management requires solid information systems able to adapt to the context needs and particularities ...
Gabriel Moreno +3 more
doaj +1 more source
Behavior Modeling on ARINC653 to Support the Temporal Verification of Conformed Application Design
IEEE Access, 2019 Numerous factors have an impact on the temporal correction of integrated modular avionics application. As early as in the design phase, verification should be conducted to guarantee the rigorous temporal requirements for safety consideration which are ...
Kui Zhang +4 more
doaj +1 more source
Software development: A paradigm for the future [PDF]
, 1989 A new paradigm for software development that treats software development as an experimental activity is presented. It provides built-in mechanisms for learning how to develop software better and reusing previous experience in the forms of knowledge ...
Basili, Victor R.
core +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
BioRel: towards large-scale biomedical relation extraction
BMC Bioinformatics, 2020 Background Although biomedical publications and literature are growing rapidly, there still lacks structured knowledge that can be easily processed by computer programs.
Rui Xing, Jie Luo, Tengwei Song
doaj +1 more source