Results 61 to 70 of about 76,374 (267)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Experimental Evaluation of Algorithmic Effort Estimation Models using Projects Clustering [PDF]

Journal of Advances in Computer Engineering and Technology, 2016
One of the most important aspects of software project management is the estimation of cost and time required for running information system. Therefore, software managers try to carry estimation based on behavior, properties, and project restrictions ...
Farzaneh Famoori, Vahid Khatibi bardsiri, Shima Javadi Moghadam, Fakhrosadat Fanian   +3 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The Implementation of Machine Learning for Software Effort Estimation: A Literature Review

Khazanah Informatika
Effort estimation is pivotal for the triumph of software development endeavors. The appropriate forecasting approach is vital for aligning software project effort estimation outcomes.
Eva Hariyanti, Mirtha Aini Paradista, Maria Lauda Joel Goyayi, Arthalia Arthalia, Detria Azka Shabirina, Endang Nurjanah, Oktavia Intifada Husna, Fakhrana Almas Syah Yahrani   +7 more
doaj   +1 more source

Peningkatan Akurasi Estimasi Usaha dan Biaya COCOMO II Berdasarkan Gaussian dan BCO

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017
An accurate effort and cost estimation provides good management for software projects. Less accurate estimation will affect the management of the software project and cause the ineffectiveness of the project development process.
Rahmi Rizkiana Putri, Daniel Oranova Siahaan, Sarwosri   +2 more
doaj   +1 more source

AI in Software Effort Estimation

This chapter delves into AI’s application in software effort and cost estimation, beginning with the foundational concepts of estimation. It highlights the challenges faced during various phases of the software development lifecycle, from planning to maintenance.
Nevena Rankovic, Dragica Ranković, Mirjana Ivanovic, Ljubomir Lazić   +3 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Hybrid Intelligent Model to Increase the Accuracy of COCOMO [PDF]

Journal of Advances in Computer Engineering and Technology, 2017
Nowadays, effort estimation in software projects is turned to one of the key concerns for project managers. In fact, accurately estimating of essential effort to produce and improve a software product is effective in software projects success or fail ...
Vida Doranipour
doaj