Results 111 to 120 of about 8,268,032 (366)
Teaching Software Development to Non-Software Engineering Students [PDF]
This paper argues that although the object-oriented programming (OOP) paradigm is appropriate for students taking programming modules on Higher Education (HE) software engineering course, this paradigm is not as relevant for students from other courses ...
Colvin, John
core
Reusability in software engineering [PDF]
, 1987 This paper surveys recent work concerning reusability in software engineering. The current directions in software reusability are discussed, and the two major approaches of reusable building blocks and reusable patterns studied. An extensive bibliography,
Seppänen, Veikko
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Engineering Trust-based Software Intensive Systems
, 2004 of a keynote speech given at the Strategic Research Workshop on Engineering Software Intensive ...
Sassone, V.
core
Developing an undergraduate software engineering degree [PDF]
, 2003 As those who have done it can attest, developing an undergraduate degree in software engineering is a daunting and challenging task, and there have been instances where a department has tried, but failed to get its program approved.
Armarego, J. +5 more
core +1 more source
Software developers' perceptions of soft skills in software requirements engineering [PDF]
Journal of Engineering Management and Competitiveness, 2018 Software requirements express users' needs and constraints for a software system to be constructed in order to solve some real problems. Both researchers and practitioners from industry point out that well performed requirements related activities have ...
Zorić Tamara, Stojanov Željko
doaj
IEEE Access, 2019 Software engineering is a data-driven discipline and an integral part of data science. The introduction of big data systems has led to a great transformation in the architecture, methodologies, knowledge domains, and skills related to software ...
Fatih Gurcan, N. Cagiltay
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source