Results 31 to 40 of about 876,365 (298)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Engineering telecommunication services with SDL [PDF]
, 1999 If formal techniques are to be more widely accepted then they should evolve as current software engineering approaches evolve. Current techniques in the development of distributed systems use interface definition languages (IDLs) as a basis for the ...
Kolberg, M., Sinnott, R.O.
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Domain-Specific Metamodelling Languages for Software Language Engineering [PDF]
, 2010 Domain-specific languages are constructed to provide modelling capabilities tailored to a specific domain. Sometimes, languages are developed many times, typically to support application in a new context. In doing so, recurring patterns and commonalities as well as variations across the evolving set of languages can be identified. This paper introduces
Zschaler, Steffen +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Incorporating Gaming in Software Engineering Projects: Case of RMU Monopoly [PDF]
Journal of Systemics, Cybernetics and Informatics, 2009 A major challenge in engineering education is retaining student interest in the engineering discipline. Active student involvement in engineering projects is one way of retaining student interest.
Sushil Acharya, David Burke
doaj
GATE -- an Environment to Support Research and Development in Natural Language Engineering [PDF]
, 1996 We describe a software environment to support research and development in natural language (NL) engineering. This environment -- GATE (General Architecture for Text Engineering) -- aims to advance research in the area of machine processing of natural ...
Cunningham, Hamish +4 more
core +4 more sources
Do Software Languages Engineers Evaluate their Languages?
, 2011 Domain Specific Languages (DSLs) can contribute to increment productivity, while reducing the required maintenance and programming expertise. We hypothesize that Software Languages Engineering (SLE) developers consistently skip, or relax, Language Evaluation.
Gabriel, Pedro +2 more
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Engineering meta-languages for specifying software languages (keynote) [PDF]
Proceedings of the 10th ACM SIGPLAN International Conference on Software Language Engineering, 2017 The programming and modelling languages currently used in software engineering generally have plenty of tool support. But although their syntax is specified using formal grammars or meta-models, complete formal semantic specifications are seldom provided.
openaire +3 more sources