Results 61 to 70 of about 46,956 (318)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Measuring the Quality of Machine Learning and Optimization Frameworks [PDF]
, 2018 Software frameworks are daily and extensively used in research, both for fundamental studies and applications. Researchers usually trust in the quality of these frameworks without any evidence that they are correctly build, indeed they could contain some
Alba-Torres, Enrique +2 more
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Why Modern Open Source Projects Fail
, 2017 Open source is experiencing a renaissance period, due to the appearance of modern platforms and workflows for developing and maintaining public code. As a result, developers are creating open source software at speeds never seen before.
Androutsellis-Theotokis Stephanos +5 more
core +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
PENGUKURAN KUALITAS WEBSITE PENGURUS CABANG NU DEPOK MENGGUNAKAN SOFTWARE METRIC
Jurnal Sisfokom, 2021 Website Pengurus Cabang Nahdlatul Ulama (PCNU) Depok dibuat sebagai sarana penyimpanan dan pengelolaan data dalam organisasi tersebut. Penelitian ini bertujuan untuk mengukur kualitas website PCNU Depok dilihat dari maintainability, flexibility dan ...
Ryan Aji Wijaya, Karmilasari
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Jurnal Sistem Informasi, 2012 Sebuah metode untuk mengukur kualitas desain berdasarkan hasil implementasinya dalam Java source codes diusulkan dalam penelitian ini. Metode yang diusulkan menggabungkan Metrics for Object-Oriented Software Engineering (MOOSE), properti kualitas desain ...
Petrus Mursanto, Efano Hermawan
doaj +3 more sources
A Complexity Metrics Suite for Cascading Style Sheets
Computers, 2019 We perform a theoretical and empirical analysis of a set of Cascading Style Sheets (CSS) document complexity metrics. The metrics are validated using a practical framework that demonstrates their viability. The theoretical analysis is performed using the
Adewole Adewumi +2 more
doaj +1 more source
Introducing Energy Efficiency into SQALE [PDF]
, 2013 Energy Efficiency is becoming a key factor in software development, given the sharp growth of IT systems and their impact on worldwide energy consumption.
Ardito, Luca +3 more
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