Results 61 to 70 of about 49,213 (322)

Longitudinal Evaluation of Open-source Software Maintainability

Proceedings of the 15th International Conference on Evaluation of Novel Approaches to Software Engineering, 2020
We present a longitudinal study on the long-term evolution of maintainability in open-source software. Quality assessment remains at the forefront of both software research and practice, with many models and assessment methodologies proposed and used over time.
Molnar, Arthur-Jozsef, Motogna, Simona
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Complexity Metrics Suite for Cascading Style Sheets

Computers, 2019
We perform a theoretical and empirical analysis of a set of Cascading Style Sheets (CSS) document complexity metrics. The metrics are validated using a practical framework that demonstrates their viability. The theoretical analysis is performed using the
Adewole Adewumi, Sanjay Misra, Robertas Damaševičius   +2 more
doaj   +1 more source

Generic approach for deriving reliability and maintenance requirements through consideration of in-context customer objectives [PDF]

, 2010
Not all implementations of reliability are equally effective at providing customer and user benefit. Random system failure with no prior warning or failure accommodation will have an immediate, usually adverse impact on operation.
J A Jones, L Warrington, Sobek D. K., Velle R., Ward A.   +4 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Introducing Energy Efficiency into SQALE [PDF]

, 2013
Energy Efficiency is becoming a key factor in software development, given the sharp growth of IT systems and their impact on worldwide energy consumption.
Ardito, Luca, Morisio, Maurizio, Procaccianti, Giuseppe, Vetro', Antonio   +3 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PEMERINGKATAN SOFTWARE APLIKASI BERDASARKAN PROPERTI KUALITAS DISAIN DAN METRICS FOR OBJECT ORIENTED SOFTWARE MENGGUNAKAN ANALYTIC HIERARCHY PROCESS

Jurnal Sistem Informasi, 2012
Sebuah metode untuk mengukur kualitas desain berdasarkan hasil implementasinya dalam Java source codes diusulkan dalam penelitian ini. Metode yang diusulkan menggabungkan Metrics for Object-Oriented Software Engineering (MOOSE), properti kualitas desain ...
Petrus Mursanto, Efano Hermawan
doaj   +3 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source