Results 101 to 110 of about 1,868,476 (276)

Deep Neural Network-Based Severity Prediction of Bug Reports

open access: yesIEEE Access, 2019
Software maintenance is an essential phase of software development. Developers employ issue tracking systems to collect bugs for software improvement. Users submit bugs through such issue tracking systems and decide the severity of reported bugs.
Waheed Yousuf Ramay   +4 more
doaj   +1 more source

Working Notes from the 1992 AAAI Workshop on Automating Software Design. Theme: Domain Specific Software Design [PDF]

open access: yes
The goal of this workshop is to identify different architectural approaches to building domain-specific software design systems and to explore issues unique to domain-specific (vs. general-purpose) software design. Some general issues that cut across the
Barstow, David   +3 more
core   +1 more source

Does OO sync with the way we think? [PDF]

open access: yes, 1998
Given that corrective-maintenance costs already dominate the software life cycle and look set to increase significantly, reliability in the form of reducing such costs should be the most important software improvement goal.
Hatton, Leslie
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Ground Software Maintenance Facility (GSMF) user's manual [PDF]

open access: yes
Instructions for the Ground Software Maintenance Facility (GSMF) system user is provided to operate the GSMF in all modes. The GSMF provides the resources for the Automatic Test Equipment (ATE) computer program maintenance (GCOS and GOAL).
Aquila, V., Derrig, D., Griffith, G.
core   +1 more source

Measuring the software process and product: Lessons learned in the SEL [PDF]

open access: yes, 1985
The software development process and product can and should be measured. The software measurement process at the Software Engineering Laboratory (SEL) has taught a major lesson: develop a goal-driven paradigm (also characterized as a goal/question/metric
Basili, V. R.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Group Maintenance Behaviors in the Decision-Making Styles of Self-Organizing Distributed Teams [PDF]

open access: yes, 2009
Businesses, universities, and other organizations are increasingly reliant on self-organizing, distributed teams which are enabled by information and communication technologies (ICTs).
Crowston, Kevin   +3 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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