Results 81 to 90 of about 770,489 (313)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A method for maintaining new software [PDF]
, 1994 This thesis describes a novel method for perfective maintenance of software which has been developed from specifications using formal transformations. The list of applied transformations provides a suitable derivation history to use when changes are made
Newton, Jennifer Louise
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
AgentReport: A Multi-Agent LLM Approach for Automated and Reproducible Bug Report Generation
Applied SciencesBug reports in open-source projects are often incomplete or low in quality, which reduces maintenance efficiency. To address this issue, we propose AgentReport, a multi-agent pipeline based on large language models (LLMs).
Seojin Choi, Geunseok Yang
doaj +1 more source
Measuring Software Modularity Based on Software Networks
Entropy, 2019 Modularity has been regarded as one of the most important properties of a successful software design. It has significant impact on many external quality attributes such as reusability, maintainability, and understandability.
Yiming Xiang +4 more
doaj +1 more source
Visualising software in cyberspace [PDF]
, 1999 The problems of maintaining software systems are well documented. The increasing size and complexity of modern software serves only to worsen matters.
Young, Peter
core
An Empirical Study of Distributed Software Maintenance
, 2002 A large software project may be distributed over multiple sites when the organization believes that there are not enough people to staff a single collocated team.
CAIVANO, DANILO +4 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source