Results 81 to 90 of about 4,695,708 (306)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A process model of maintenance with reuse: an investigation and an implementation abstract [PDF]

, 1997
Sixty to eighty per cent of the software life-cycle cost is spent on the software maintenance phase because software maintenance is usually more difficult than original development and legacy systems are generally large and complex.
Kwon, Oh Cheon
core  

Code Comprehension Gaps in AI-Assisted Development: A Conceptual Framework for Knowledge Erosion Patterns

IEEE Access
The increasing adoption of AI-powered code generation tools has introduced a critical challenge in software engineering, the potential erosion of developer comprehension of codebases increasingly composed of AI-generated artifacts.
Minav Suresh Patel, Rohit Dhawan, Likhesh Bramhanwade, Dibya Jyoti Mishra   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Enhancing Bug Report Summaries Through Knowledge-Specific and Contrastive Learning Pre-Training

IEEE Access
Bug reports are crucial in software maintenance, with concise summaries significantly enhancing the efficiency of bug triagers and ultimately contributing to the development of high-quality software products. Contemporary methods for automatic bug report
Yunna Shao, Bangmeng Xiang
doaj   +1 more source

Software maintenance: an approach towards control

Proceedings IEEE International Conference on Software Maintenance. ICSM 2001, 2002
In this paper the software maintenance process will be looked at in more detail from a control point of view. From this it can be seen that in most situations no proper control mechanisms exist and that even the basic requirements for control are not fulfilled. The remainder of the paper will be devoted towards describing a basic approach that provides
Rob J. Kusters, Fred J. Heemstra
openaire   +6 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Inverse software configuration management [PDF]

, 1998
Software systems are playing an increasingly important role in almost every aspect of today’s society such that they impact on our businesses, industry, leisure, health and safety. Many of these systems are extremely large and complex and depend upon the
McCrindle, Rachel Jane
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Computing ripple effect for software maintenance

, 2001
Recent software maintenance models have included impact analysis and accounting for ripple effect as one of their stages. This paper describes and explains the reformulation of Yau and Collofello's ripple-effect algorithm and its validity within the ...
Black, S.E.
core   +1 more source