Results 101 to 110 of about 4,695,708 (306)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The maintenance implications of the customization of ERP software [PDF]
, 2001 Enterprise resource planning (ERP) software is a dominant approach for dealing with legacy information system problems. In order to avoid invalidating maintenance and development support from the ERP vendor, most organizations reengineer their business ...
Light, BA, Ben Light, Light, Ben
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A method for maintaining new software [PDF]
, 1994 This thesis describes a novel method for perfective maintenance of software which has been developed from specifications using formal transformations. The list of applied transformations provides a suitable derivation history to use when changes are made
Newton, Jennifer Louise
core
Effort-Aware Fault-Proneness Prediction Using Non-API-Based Package-Modularization Metrics
MathematicsSource code complexity of legacy object-oriented (OO) software has a trickle-down effect over the key activities of software development and maintenance. Package-based OO design is widely believed to be an effective modularization. Recently, theories and
Mohsin Shaikh +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Prediction of software maintenance costs. [PDF]
This thesis is concerned with predicting the costs of maintaining a computer programprior to the software being developed. The ubiquitous nature of software means thatsoftware maintenance is an important activity, and evidence exists to support ...
Morrison, David J.
core
An Empirical Study of Distributed Software Maintenance
, 2002 A large software project may be distributed over multiple sites when the organization believes that there are not enough people to staff a single collocated team.
CAIVANO, DANILO +4 more
core +1 more source
Measuring Software Modularity Based on Software Networks
Entropy, 2019 Modularity has been regarded as one of the most important properties of a successful software design. It has significant impact on many external quality attributes such as reusability, maintainability, and understandability.
Yiming Xiang +4 more
doaj +1 more source