Results 91 to 100 of about 4,695,708 (306)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Early detection of ripple propagation in evolving software systems [PDF]
, 1993 Ripple effect analysis is the analysis of the consequential knock on effects of a change to a software system. In the first part of this study, ripple effect analysis methods are classified into several categories based on the types of information the ...
Turner, Richard john
core
an empirical analysis on distribution patterns of software maintenance effort
, 2008 IEEE, IEEE Comp Soc, IEEE Comp Soc TCSE, Reengineering Forum, Shandong CVICSE Middleware, OW2 Consortium, Beijing Simpleware TechDistribution of effort in software engineering process has been the basis for facilitating more reasonable software ...
Wang Qing, Li Qi, Yang Ye, Li Mingshu
core +2 more sources
Improving Maintenance-Consistency Prediction During Code Clone Creation
IEEE Access, 2020 Developers frequently introduce code clones into software through the copy-and-paste operations during the software development phase in order to shorten development time.
Fanlong Zhang +2 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Software maintenance by program transformation in a wide spectrum language [PDF]
, 1994 This thesis addresses the software maintenance problem of extracting high-level designs from code. The investigated solution is to use a mathematically-based formal program transformation system.
Bull, Tim
core
, 2017 Many software projects adopt mailing lists for the communication of developers and users. Researchers have been mining the history of such lists to study communities' behavior, organization, and evolution. A potential threat of this kind of study is that
Steinmacher, I. +4 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source