Results 51 to 60 of about 1,789,157 (322)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Scientific Software: Legacy Software Maintenance
Journal of Computer Science and Technology, 2016 Software production and maintenance is one of the most widely studied topics in computer science. Taking into account that scientists were the first ones to perform this task, even before the Computer Science discipline obtained its name, scientific ...
Mariano Méndez
doaj
Exploring Code Clones in Programmable Logic Controller Software
, 2017 The reuse of code fragments by copying and pasting is widely practiced in software development and results in code clones. Cloning is considered an anti-pattern as it negatively affects program correctness and increases maintenance efforts.
Egyed, Alexander +3 more
core +1 more source
Code Flows: Visualizing Structural Evolution of Source Code [PDF]
, 2008 Understanding detailed changes done to source code is of great importance in software maintenance. We present Code Flows, a method to visualize the evolution of source code geared to the understanding of fine and mid-level scale changes across several ...
Auber, David,, Telea, Alexandru,
core +8 more sources
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
A Refactoring Classification Framework for Efficient Software Maintenance
IEEE Access, 2023 The expenses associated with software maintenance and evolution constitute a significant portion, surpassing more than 80% of the overall costs involved in software development.
Abdullah Almogahed +8 more
doaj +1 more source
A software architecture for autonomous maintenance scheduling: Scenarios for UK and European Rail [PDF]
, 2016 A new era of automation in rail has begun offering developments in the operation and maintenance of industry standard systems. This article documents the development of an architecture and range of scenarios for an autonomous system for rail maintenance ...
Blacktop, K. +4 more
core +1 more source