Results 61 to 70 of about 346,980 (259)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Development time estimation using software metrics
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The article describes investigation of the ability to use software metrics for development time estimation of existing software product as well as investigation of the ability to predict development time of new software product at the design stage ...
Y. V. Liah
doaj
Improving the Security of UML Sequence Diagram Using Genetic Algorithm
IEEE Access, 2020 A sequence diagram is a modeling approach for visualizing the behavioral execution of a system. The objective of this research is to investigate the problem of security in a behavioral model (sequence diagram) through the application of model refactoring.
Mohammad Alshayeb +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Assessing Evolution of Microservices Using Static Analysis
Applied SciencesMicroservices have gained widespread adoption in enterprise software systems because they encapsulate the expertise of specific organizational subunits. This approach offers valuable insights into internal processes and communication channels.
Amr S. Abdelfattah +5 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Entropy Churn Metrics for Fault Prediction in Software Systems
Entropy, 2018 Fault prediction is an important research area that aids software development and the maintenance process. It is a field that has been continuously improving its approaches in order to reduce the fault resolution time and effort.
Arvinder Kaur, Deepti Chopra
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Application of Blockchain Technologies in Verification of Software Metrics
Applied SciencesWhen creating software, it is important to focus not only on the functionality requested by users but also on ensuring that the software exhibits qualities such as maintainability, testability, comprehensibility, and reusability.
Jovan Milutinović +4 more
doaj +1 more source