Results 71 to 80 of about 891,695 (342)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Applying Software Metrics to evaluate Business Process Models
CLEI Electronic Journal, 2006 In this paper, we define a set of metrics for the evaluation of conceptual models of business processes. The proposal supposes the adaptation and extension of the FMESP framework (Framework for the Modeling and Evaluation of Software Processes).
Elvira Rolón +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
A Framework for Measuring Security as a System Property in Cyberphysical Systems
Information, 2016 This paper addresses the challenge of measuring security, understood as a system property, of cyberphysical systems, in the category of similar properties, such as safety and reliability.
Janusz Zalewski +5 more
doaj +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
An Approach to Evaluate the Complexity of Block-Based Software Product
Informatics in Education, 2020 Computer programming skills have been growing as a professional competence also to unqualified end-users who need to develop software in their professional practice. Quality evaluation models of end-user-developed products are still scarce. In this paper,
Ilenia FRONZA, Luis CORRAL, Claus PAHL
doaj +1 more source
Software metrics: Software quality metrics for distributed systems [PDF]
Software quality metrics was extended to cover distributed computer systems. Emphasis is placed on studying embedded computer systems and on viewing them within a system life cycle.
Post, J. V.
core +1 more source
Defect prediction with bad smells in code [PDF]
, 2017 Background: Defect prediction in software can be highly beneficial for development projects, when prediction is highly effective and defect-prone areas are predicted correctly.
Dąbrowska, Marta +3 more
core +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Using Neural Networks In Software Metrics [PDF]
Software metrics provide effective methods for characterizing software. Metrics have traditionally been composed through the definition of an equation, but this approach is limited by the fact that all the interrelationships among all the parameters be ...
Ion I. Bucur, Nicolae Begnescu
core