Results 71 to 80 of about 4,534,833 (370)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Metrics Are Needed for Collaborative Software Development [PDF]

Journal of Systemics, Cybernetics and Informatics, 2011
There is a need for metrics for inter-organizational collaborative software development projects, encompassing management and technical concerns. In particular, metrics are needed that are aimed at the collaborative aspect itself, such as readiness for ...
Mojgan Mohtashami, Cyril S. Ku, Thomas J. Marlowe   +2 more
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Applying Software Metrics to evaluate Business Process Models

CLEI Electronic Journal, 2006
In this paper, we define a set of metrics for the evaluation of conceptual models of business processes. The proposal supposes the adaptation and extension of the FMESP framework (Framework for the Modeling and Evaluation of Software Processes).
Elvira Rolón, Francisco Ruiz, Félix García, Mario Piattini   +3 more
doaj   +1 more source

Assessment of the total software product development time [PDF]

Војно дело, 2016
The main motive of this paper on software engineering is to confront the engineering approach to the software development with the artistic one. Software engineering is the youngest engineering discipline and, as such, it still involves a high degree of ...
Živadinović Jovan, Medić Zorica, Jevtić Boris   +2 more
doaj   +1 more source

Defect prediction with bad smells in code [PDF]

, 2017
Background: Defect prediction in software can be highly beneficial for development projects, when prediction is highly effective and defect-prone areas are predicted correctly.
Dąbrowska, Marta, Hryszko, Jarosław, Konopka, Piotr, Madeyski, Lech   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Google Scholar citations: a way for academics to compute citation metrics and track them over time [PDF]

, 2011
Citation metrics are used by many academics and researchers to gauge the influence of their work, and to gain a better understanding of the impact of their research.
Blog Admin, Impact of Social Sciences,
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source