Results 131 to 140 of about 67,834 (260)
Design Patterns and Component Framework for Building RTSJ-Based Real-Time Middleware [PDF]
, 2010 The middleware is a software layer located on top of the operating system that uses its facilities, integrates with it, and extends its functionality in order to support the development of effective and reliable distributed systems; however, the ...
Alrahmawy, Mohammed
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityObject-Oriented design and development dominates both commercial and open source software projects.
Gatrell, Matt
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Automated Detection of Software Design Patterns: A Systematic and Comparative Survey
IEEE AccessDesign patterns capture reusable solutions to recurring design problems and play a central role in program comprehension, software maintenance, and software evolution.
Mohammed Ghazi Al-Obeidallah
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Exploring the Connection between the TDD Practice and Test Smells—A Systematic Literature Review
ComputersTest-driven development (TDD) is an agile practice of writing test code before production code, following three stages: red, green, and refactor. In the red stage, the test code is written; in the green stage, the minimum code necessary to make the test ...
Matheus Marabesi +2 more
doaj +1 more source
2018 ACM/IEEE International Workshop on Software Fairness: Fairware (ACM 2018)
, 2018 Software Design Patterns (SDPs) are core solutions to the recurring problems in software. However, adopting SDPs without taking into account their value implications may result in breach of social values and ultimately lead to user dissatisfaction, lack ...
Mougouei, Davoud +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source