Results 121 to 130 of about 7,115,919 (304)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ComputersModern software systems consist of many software components; the source code of modern software systems is hard to understand and maintain for new developers.
Artyom V. Gorchakov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
IEEE AccessOrganizational patterns can be applied to correct problems or build a new organization from scratch. Security patterns can help organizations develop secure software.
Viktor Matovic, Valentino Vranic
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Patterns and Software: Essential Concepts and Terminology
, 1998 that provides a short summary or overview. This gives readers a clear picture of the pattern and quickly informs them of its relevance to any problems they may wish to solve (sometimes such a description is called a thumbnail sketch of the pattern, or a ...
Introducing Patterns, Brad Appleton
core
Combining Structural Features and Software Metrics for Automated Design Pattern Detection
IEEE AccessDesign patterns provide reusable solutions to recurring software design problems. Since their introduction by the Gang of Four in 1994, identifying these patterns in object-oriented programs has remained a challenging task, particularly with regard to ...
Mohammed Ghazi Al-Obeidallah
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Digital Modeling and Visualization of Embroidery Techniques
Digital Presentation and Preservation of Cultural and Scientific HeritageThis paper deals with problems related to digital presentation and preservation of handmade embroidery in the following aspects: techniques, master skills and numerous embroidery patterns created by generations of craftsmen.
Elena Zaharieva-Stoyanova, Stefan Bozov
doaj +1 more source