Results 101 to 110 of about 67,834 (260)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2015 Technology rms are increasingly opening up their products to develop an active ecosystem of developing partners around it. Both opening up products and organizing a developer ecosystem around an or- ganization are non-trivial.
Software Production +3 more
core +1 more source
Energy Efficiency in the ICT - Profiling Power Consumption in Desktop Computer Systems [PDF]
, 2012 Energy awareness in the ICT has become an important issue. Focusing on software, recent work suggested the existence of a relationship between power consumption, software configuration and usage patterns in computer systems.
Ardito, Luca +13 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Architectural patterns regarding web application domain usability
Ingeniería e Investigación, 2010 Usability is one of the quality characteristics having the greatest impact on final user acceptation in a web application context. However, the relationship between usability and software architecture has not been completely identified and characterised.
José Luis Arciniegas Herrera +4 more
doaj
Design Patterns for Wrapping Similar Legacy Systems with Common Service Interfaces
, 2006 Web Services are increasingly being used to create a wide range of distributed systems, many of which involve legacy software. Developing service interfaces for these legacy systems can be difficult, as for interoperability reasons it is advantageous to ...
Lester Gilbert +13 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
MuscleX: data analysis software for fiber diffraction patterns from muscle
Journal of Synchrotron RadiationMuscleX is an integrated, open-source computer software suite for data reduction of X-ray fiber diffraction patterns from striated muscle and other fibrous systems. It is written in Python and runs on Linux, Microsoft Windows or macOS.
Jiranun Jiratrakanvong +14 more
doaj +1 more source
Software and Application Patterns for Explanation Methods [PDF]
, 2019 Deep neural networks successfully pervaded many applications domains and are increasingly used in critical decision processes. Understanding their workings is desirable or even required to further foster their potential as well as to access sensitive domains like medical applications or autonomous driving.
openaire +2 more sources